Dental Anesthesia Key Players and Future Market Positioning

Top Companies in the Dental Anesthesia Market

• Aseptico
• B. Braun Medical
• Carestream Dental
• Dentsply Sirona
• Henry Schein
• Hu-Friedy
• Kerr Dental
• Medline Industries
• Milestone Scientific
• Novocol Pharmaceuticals
• Septodont
• Septodont/Septodont group (regional brands and cartridges)
• Smiths Medical
• Ultradent Products
• Vatech / A-dec
• Zimmer Biomet Dental / Align Technology

Market Forecast

The global dental anesthesia market size marked US$ 2.35 billion in 2024 and is forecast to experience consistent growth, reaching US$ 2.45 billion in 2025 and US$ 3.61 billion by 2034 at a CAGR of 4.52%.

Dental Anesthesia Market Trends

Robotic Assistance in Dental Procedures

• Robotic assistance in dental procedures is significantly influencing the dental anesthesia market by enhancing surgical precision, reducing patient discomfort, and improving overall treatment outcomes. A notable example is the Yomi robotic system by Neocis, which has been integrated into dental implant surgeries.
• In March 2025, dental students at the University of Buffalo participated in an "AI Implant Immersion Experience," where they interacted with the Yomi robot and explored its capabilities in assisting with implant surgeries. This hands-on experience highlighted the potential of robotic systems to streamline dental procedures, potentially reducing the need for extensive anesthesia by minimizing surgical invasiveness. As such technologies become more prevalent, they are expected to drive the demand for advanced anesthetic solutions, thereby propelling growth in the dental anesthesia market.

Adoption of Inorganic Growth Strategies

Inorganic growth strategies such as partnerships, acquisitions, and collaborations are significantly influencing the dental anesthesia market.

• In January 2025, Branford Castle Partners acquired Eastern Dental Management, a dental group with 20 locations in New Jersey, from Staple Street Capital.  These strategic moves enable companies to expand their product portfolios, enhance technological capabilities, and enter new geographic markets swiftly, thereby accelerating the adoption of advanced anesthetic solutions and propelling market growth.

Value Chain Analysis

R&D

• Target Discovery & Molecule Research – Identifying new anesthetic agents or improving existing formulations.
• Organizations: Septodont, Dentsply Sirona, Pfizer.
• Formulation Development – Creating buffered, long-acting, and patient-friendly anesthetic formulations.
• Organizations: Septodont, 3M Oral Care, Pierrel Pharma.
• Delivery Device Innovation – Advancing computer-controlled local anesthetic delivery (CCLAD), needle-free systems.
• Organizations: Milestone Scientific, Anutra Medical.
• Preclinical Testing – Safety, efficacy, and stability testing in labs and animal models.
• Organizations: In-house labs of manufacturers, CROs (Contract Research Organizations).

Clinical Trial and Approval

• Phase I – Safety and dosage trials on small groups of healthy volunteers.
• Organizations: CROs like ICON, PPD, and in-house research units.
• Phase II – Testing efficacy and side effects in dental patients.
• Organizations: University dental schools, clinical research hospitals.
• Phase III – Large-scale comparative studies with existing anesthetics.
• Organizations: Mayo Clinic, European Dental Research Centers, FDA-supervised U.S. hospitals.
• Regulatory Approval – Submission of data to regulators.
• Organizations: FDA (U.S.), EMA (Europe), PMDA (Japan), CDSCO (India).

Patient Service and Support

• Patient Assessment – Medical history, allergy testing, and selection of suitable anesthesia.
• Organizations: Private dental clinics, hospital dental departments.
• Administration & Monitoring – Delivering anesthesia with modern devices and monitoring vitals.
• Organizations: General dental practices, ASCs, hospitals.
• Post-Procedure Care & Safety Reporting – Pain management, follow-ups, and reporting adverse effects.
• Organizations: American Dental Association (ADA), European Federation of Periodontology, local dental councils.
• Training & Support – Educating dentists on device use and anesthetic protocols.
• Organizations: Dentsply Sirona Training Centers, Septodont education programs, university workshops.

Latest Announcement by Industry Leaders

In August 2025, Gregory T. Lucier, Chairman of the Board stated that the Dentsply Sirona company appointed Daniel Scavilla as CEO effective August 1, 2025. Scavilla has a background with Globus Medical, and is expected to help with strategic execution and possibly more M&A activity.  Along with that, Dentsply Sirona reaffirmed its financial guidance for Q2 2025 and reported preliminary net sales of about US$935-936 million. These results were seen positively by the market.

Recent Development in the Dental Anesthesia Market

• In September 2025, Dentalhitec Americas announced the U.S. launch of QuickSleeper5, following FDA clearance. This digital, computer-guided anesthesia delivery system enables true intraosseous anesthesia with immediate onset. The device is designed to eliminate common issues like prolonged soft-tissue numbness while providing faster, more predictable anesthesia, making dental procedures smoother for both patients and practitioners.
• In 2025, Septodont Inc. and Premier Dental jointly launched BufferPro, a single-use sterile sodium bicarbonate capsule. This innovation allows dentists to buffer local anesthetic cartridges in a simple one-step process, helping reduce injection discomfort and speed up the onset of anesthesia. The convenience and effectiveness of BufferPro aim to enhance the patient experience while improving workflow efficiency for clinicians.
• In June 2025, VCS Medical received FDA clearance for DentalJect, a breakthrough topical anesthetic delivery system. Unlike traditional gels that require waiting time, DentalJect uses a drug-free cryogenic spray to numb oral tissues such as the palate and gingiva in less than two seconds. This rapid and non-invasive approach allows for immediate follow-up injections, offering a faster, more comfortable alternative for patients.

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