Towards Healthcare
U.S. Biopharmaceutical Third-party Logistics Market
Updated Date: 01 December 2025   |   Report Code: 5661

U.S. Biopharmaceutical Third-party Logistics Market Landscape, Future Trends and Growth Pathways

Market insights predict, the U.S. biopharmaceutical third-party logistics industry is expected to grow from USD 61.08 billion in 2025 to USD 127.06 billion by 2035, driven by a CAGR of 7.6%. Rising complexities and volume of biopharmaceutical products like monoclonal antibodies and gene therapies, and also, branded drugs, are driving the growth of the market.

Last Updated : 01 December 2025 Category: Healthcare Services Insight Code: 5661 Format: PDF / PPT / Excel

Content

Introduction

  • Definition and scope of biopharmaceutical third-party logistics

  • Importance of 3PL in the U.S. pharmaceutical supply chain

  • Methodology and data sources used in the report

Market Dynamics

  • Market drivers

    • Rising demand for temperature-controlled logistics

    • Increasing outsourcing of logistics functions

    • Expansion of biopharmaceutical R&D and clinical trials

  • Market restraints

    • High cost of cold chain infrastructure

    • Regulatory complexity and compliance

  • Market opportunities

    • Integration of digital tracking and real-time monitoring

    • Sustainable logistics solutions

    • Growth of personalized medicine and cell & gene therapy

Regulatory Landscape

  • FDA and DEA regulations affecting pharmaceutical logistics

  • Good Distribution Practices (GDP) and quality assurance standards

  • Requirements for cold chain and controlled substances handling

  • Impact of healthcare reforms and trade policies

Market Segmentation

By Supply Chain

Cold Chain Logistics

  • Market size and growth potential

  • Role in transporting vaccines, biologics, and temperature-sensitive drugs

  • Infrastructure needs: refrigerated transport, insulated packaging, monitoring

  • Innovations and automation in cold chain logistics

Non-cold Chain Logistics

  • Market analysis and applications

  • Handling of oral solids, injectables, and generics

  • Emphasis on scalability, speed, and compliance

  • Cost-efficiency and network optimization strategies

By Service Type

Warehousing and Storage

  • Importance of GMP-compliant storage facilities

  • Trends in automated and climate-controlled warehousing

  • Regional distribution centers and strategic locations

Transportation

  • Overview of transportation solutions for biopharmaceuticals

  • Integration of end-to-end visibility and temperature control

  • Compliance with regulations during transit

Air Freight

  • Use in high-value, time-sensitive pharmaceutical shipments

  • Temperature-controlled air cargo services

  • Airport infrastructure and cold storage readiness

Sea Freight

  • Cost-effective solution for large volume shipments

  • Use of refrigerated containers and passive packaging

  • Longer transit times and compliance considerations

Overland

  • Road and rail transport for short and mid-range routes

  • Fleet innovations and IoT-based monitoring systems

  • Last-mile delivery and cross-docking operations

Other Services

  • Labeling, packaging, and kitting

  • Customs clearance and regulatory documentation

  • Reverse logistics and returns management

Go-to-Market Strategies (Europe/Asia Pacific/North America/Latin America/Middle East)

  • Regional Market Penetration Techniques

  • Strategic Partnerships and Alliances

  • Local Market Adaptation and Cultural Considerations

  • Distribution Network Design and Optimization

  • Competitive Positioning by Geography

Healthcare Production & Manufacturing Data

  • Overview of Biopharmaceutical Manufacturing in the U.S.

  • Data Trends in Drug and Vaccine Production

  • Key Players in Biopharmaceutical Manufacturing

  • Production Facility Locations and Capacity

Cross-Border Healthcare Services

  • Role of International Logistics in Healthcare

  • Import/Export Requirements for Pharmaceuticals

  • Cross-border Cold Chain Management

  • Risk Mitigation Strategies in Cross-border Transport

Regulatory Landscape & Policy Insights in Healthcare Market

  • U.S. Healthcare Policy Overview

  • Impact of Compliance Requirements on 3PL Providers

  • Policy Shifts Affecting Biopharma Logistics

Regulatory Environment by Region: In-depth Analysis of FDA (US), EMA (Europe), MHRA (UK), NMPA (China)

  • Comparative Analysis of Global Regulatory Authorities

  • Labeling, Packaging, and Serialization Standards

  • Approval Pathways and Timeline Differences

Impact of Regulatory Changes on Market

  • Adaptation Strategies for Regulatory Shifts

  • Cost Implications for Third-party Logistics

  • Case Studies on Regulatory Disruption

Government Healthcare Spending and Policies

  • U.S. Federal and State Healthcare Budgets

  • Influence on Biopharma Supply Chain Development

  • Public-private Collaborations and Initiatives

Technological Disruption and Innovations

  • Key Innovations Shaping Logistics and Distribution

  • Role of Automation and Digitization in 3PL Services

  • Tech Adoption Barriers and Opportunities

Global Healthcare Production Insights

  • International Benchmarks for Biopharma Production

  • Key Export and Import Markets

  • Growth Patterns in Emerging and Developed Markets

Advanced Manufacturing Techniques

  • Smart Manufacturing and IoT Integration

  • Automation and Robotics in Drug Production

  • Real-time Monitoring and Control

AI & Machine Learning in Healthcare

  • Predictive Analytics for Supply Chain Forecasting

  • AI-powered Route Optimization

  • Demand Planning Using ML Models

Wearables and Remote Monitoring

  • Integration into Logistics via Real-time Tracking

  • Impacts on Cold Chain Management

  • Enabling Patient-centric Delivery Models

Blockchain in Healthcare

  • Enhancing Supply Chain Transparency

  • Data Security and Traceability

  • Real-world Blockchain Use Cases in Biopharma Logistics

3D Printing and Bioprinting

  • Customization of Medical Supplies

  • On-demand Drug Production

  • Logistical Implications for 3D Biomanufacturing

Consumer Adoption and Digital Health

  • Trends in Patient Engagement and Mobile Health

  • Delivery Preferences and Last-mile Logistics

  • Role of ePharmacies in 3PL Demand

Investment and Funding Insights in Healthcare

  • Capital Inflow in Healthcare Logistics Startups

  • Role of Government Grants and Incentives

  • Infrastructure Investment Trends

  • Key Investors in Healthcare Logistics

  • Hotspots for Biopharma VC Activity

  • Exit Strategies and IPO Performance

Venture Funding in Biotech

  • Startups Disrupting the Biopharma Value Chain

  • Funding Rounds and Valuation Trends

  • Logistics Innovations Backed by Biotech Investors

Mergers and Acquisitions in Healthcare

  • Strategic Acquisitions in the 3PL Space

  • Consolidation Trends in Biopharma Logistics

  • Impact on Service Capabilities and Reach

Entry Strategies for Emerging Markets

  • Risk Evaluation and Regulatory Entry Barriers

  • Localization Tactics for New Market Penetration

  • Establishing Regional Hubs and Warehouses

Strategic Role of Healthcare Ecosystems

  • Collaboration Among Payers, Providers, and Distributors

  • Ecosystem Mapping for Biopharma Logistics

  • Network Effects and Synergies

Healthcare Investment and Financing Models

  • Capital Allocation for Logistics Infrastructure

  • Public-Private Investment Models

  • Cost-sharing Mechanisms Across Stakeholders

Private Equity and Venture Capital in Healthcare

  • Growth Drivers for PE Interest in Logistics

  • Portfolio Strategies in Biopharma Support Services

  • Case Studies of PE-led Expansion

Innovative Financing Models in Healthcare

  • Outcome-based Logistics Contracts

  • Subscription and Pay-as-you-go Logistics Services

  • Crowdfunding and Community-based Models

Sustainability and ESG (Environmental, Social, Governance) in Healthcare

  • Green Logistics Practices in Biopharma

  • ESG Metrics in Supply Chain Management

  • Reporting Standards and Compliance

Smart Tracking and Inventory Management

  • Real-time Tracking Systems

  • RFID, GPS, and IoT Solutions

  • Inventory Optimization Tools

Enhanced Efficiency and Productivity

  • Lean Logistics in Biopharmaceuticals

  • Route and Load Optimization

  • Warehouse Automation and Robotics

Cost Savings and Waste Reduction

  • Cold Chain Efficiency Enhancements

  • Reducing Expired and Damaged Goods

  • Packaging Innovations for Cost Control

Global Production Volumes

  • Key Metrics in Biopharma Output

  • Volume Trends Across Product Categories

  • Leading Producers and Regions

Regional Production Analysis

  • U.S. Production Hubs and Capabilities

  • Comparison with Global Manufacturing Centers

  • Outsourcing vs. Onshore Manufacturing

Consumption Patterns by Region

  • U.S. Pharmaceutical Demand Trends

  • Therapeutic Segments Driving Growth

  • Impact of Demographic and Health Data

  • Personalized Medicine and Its Impact

  • Vaccine and Biologics Demand Surges

  • Generic vs. Branded Drug Distribution Trends

Opportunity Assessment

  • Growth Potential by Therapeutic Area

  • White Spaces in Biopharma Logistics

  • Innovation-driven Expansion Areas

Plan Finances/ROI Analysis

  • Cost-benefit of Third-party Logistics Adoption

  • ROI Calculation Models for 3PL Engagement

  • Long-term Value Creation Metrics

Supply Chain Intelligence/Streamline Operations

  • Integrated Data Platforms for Visibility

  • KPI Tracking and Performance Benchmarking

  • Predictive Modeling for Disruption Prevention

Cross-border Intelligence

  • Trade Route Optimization

  • Compliance and Tariff Navigation

  • Emergency Cross-border Protocols

Business Model Innovation

  • Platform-based Logistics Ecosystems

  • Pharma-as-a-Service Delivery Models

  • Subscription Logistics and Drone Delivery

Case Studies and Examples

  • Leading 3PL Success Stories in U.S. Biopharma

  • Innovation-led Logistics Partnerships

  • Real-world Impact of Tech Adoption in Logistics

Future Prospects and Innovations

  • Evolution of Biopharma Supply Chain Networks

  • Smart Logistics Hubs of the Future

  • Next-gen Biologistics Technologies

Top Companies in the U.S. Biopharmaceutical Third-Party Logistics Market

  • UPS Healthcare

    • Cold chain capabilities and smart tracking solutions

  • Cardinal Health

    • Nationwide distribution network and specialized packaging

  • KUEHNE + NAGEL

    • End-to-end pharma logistics and GDP-certified services

  • AmerisourceBergen Corp.

    • Integrated logistics and pharmaceutical distribution expertise

  • McKesson Corporation

    • Extensive warehousing and transportation infrastructure

  • Thermo Fisher Scientific

    • Clinical supply chain management and lab logistics

  • DHL International GmbH

    • Global reach with specialized life sciences logistics

  • DB Schenker

    • Sustainable logistics and real-time tracking systems

  • Kerry Logistics Network Ltd.

    • Customized supply chain solutions and pharmaceutical hubs

  • CEVA Logistics

    • Dedicated healthcare and pharmaceutical logistics division

  • Agility Logistics

    • Flexible logistics models and temperature-controlled transport

  • SF Express

    • High-speed domestic distribution and tracking tech

  • XPO Logistics

    • Innovative overland pharma transport and warehousing

  • Cencora, Inc.

    • Comprehensive healthcare logistics and patient services

  • EVERSANA

    • Integrated commercialization services and specialty logistics

Competitive Landscape and Market Share Analysis

  • Company profiles and SWOT analysis

  • Strategic collaborations and partnerships

  • Mergers, acquisitions, and service expansions

  • Comparative market positioning

Future Outlook and Forecast

  • Emerging trends shaping the biopharma 3PL market

  • Projected market size and CAGR

  • Strategic recommendations for stakeholders

FAQ's

Answer : The main applications of third-party logistics are arrangements or managing numerous supply chain functions for a business, including mediating, shipping, storing, or packing a companys freight, as well as supply chain plans and approach to technology.

Answer : 3PL services mainly comprise warehousing and storage, transportation, International Transportation Management (ITM) and Domestic Transportation Management (DTM), and Value-Added Services (VAS).

Answer : The U.S. biopharmaceutical third-party logistics market in 2026 is valued at USD 65.72 billion and is projected to climb to USD 127.06 billion by 2035, with a CAGR of 7.6% over the forecast period.

Meet the Team

Deepa Pandey is a focused and detail-oriented market research professional with growing expertise in the healthcare sector, delivering high-quality insights across therapeutic areas, diagnostics, biotechnology and healthcare services.

Learn more about Deepa Pandey

Aditi Shivarkar is a seasoned professional with over 14 years of experience in healthcare market research. As a content reviewer, Aditi ensures the quality and accuracy of all market insights and data presented by the research team.

Learn more about Aditi Shivarkar