U.S. Pain Management Drugs Market Manufacturers, Recent Developments and Strategic Involvements

U.S. Pain Management Drugs Market Top Companies

• AbbVie Inc.
• Amgen Inc.
• AstraZeneca
• Bayer AG
• Bristol-Myers Squibb
• Endo International plc
• GlaxoSmithKline (GSK)
• Indivior PLC
• Johnson & Johnson (Janssen Pharmaceuticals)
• Mallinckrodt Pharmaceuticals
• Novartis AG
• Pfizer Inc.
• Purdue Pharma L.P.
• Teva Pharmaceutical Industries Ltd.
• Viatris Inc.

U.S. Pain Management Drugs Market Growth

The U.S. pain management drugs market size is calculated at US$ 31.84 billion in 2024, grew to US$ 32.99 billion in 2025, and is projected to reach around US$ 44.92 billion by 2034. The market is expanding at a CAGR of 3.64% between 2025 and 2034.

What are the Trends in the Market?

Government support & guidance: The U.S. pain management drugs market is driven by the rising support and actions taken by various government organizations like the FDA, NIG, ACOG, etc. These organizations are developing guidance for the safe usage of pain management drugs. Organizations like the NIH are involved in developing new drugs, which further boosts the growth of the market.

For instance,

• In May 2025, long-awaited guidelines on pain management for in-office cervical and uterine operations were announced by the American College of Obstetricians and Gynaecologists (ACOG). It talks about how important it is to advise patients on pain management strategies and choices for routine operations.

U.S. Pain Management Drugs Market Value Chain Analysis

R&D

Discovery, which identifies a target and possible compounds; preclinical research, which tests the drug in labs and on animals; clinical trials (phase 1, 2, and 3) which test the drug's safety and efficacy in humans; regulatory review, which submits data for approval by agencies such as the FDA; and post-market surveillance, which is continuous safety monitoring after the drug is on the market.

Top Companies Include: Johnson & Johnson, Pfizer, Merck, Novartis, Abbott, Vertex Pharmaceuticals, and Latigo Biotherapeutics

Formulation and Final Dosage Preparation

For standardised items like ibuprofen, pain management medications are manufactured through mass production. For some patient needs, compounding pharmacies provide unique, customised formulations, such as mixing chemicals to create a topical cream.

Top Companies Include: Johnson & Johnson, Pfizer, Merck, Novartis, Abbott, Vertex Pharmaceuticals, and Latigo Biotherapeutics

Patient Support and Services

Accurate pain assessment, patient education on risks (such as opioid addiction), access to support services like counselling and Cognitive Behavioural Therapy (CBT), and cooperative care planning to address concerns, side effects, and functional limitations are all essential components of patient support and services.

Latest Announcements by Industry Leaders

In April 2024, AtriCure President and CEO Michael Carrel said, I think CryoSPHERE+ is a significant innovation that will improve patient care, enhance outcomes, and allow physicians to perform procedures with greater ease and confidence. With this launch, we want to serve even more people in the future. Since the beginning of our pain management franchise more than five years ago, we have witnessed a tremendous impact on patients' lives.

Recent Developments in the Market

• In February 2025, the first new kind of painkiller to be licenced in almost 20 years was approved by the US Food and Drug Administration on Thursday. After a higher initial dosage, the medication, suzetrigine, is given as a 50-milligram prescription tablet every 12 hours. The brand name Journavx will be used for its sale.
• In May 2025, Glimmer Health is a brand-new company founded by UPMC Enterprises and Redesign Health. The business collaborates with primary care physicians to enhance pain treatment through a customised, all-encompassing strategy.

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