Single-Use Mixers Market Trends Shift Toward Automated Mixing

Single-Use Mixers Market Size, Key Players with Shares and Forecast

The global single-use mixers market size is calculated at USD 1.73 billion in 2025, grew to USD 1.88 billion in 2026, and is projected to reach around USD 3.6 billion by 2034. The market is expanding at a CAGR of 8.54% between 2024 and 2034.

The single-use mixers market is primarily driven by the need to streamline manufacturing processes and the increasing development of biologics. Single-use mixers are cost-effective and reduce the manufacturing timelines. Government bodies support the adoption of single-use mixers in labs and manufacturing sites by providing funding. Artificial intelligence (AI) introduces automation in mixers, enhancing efficiency and precision. Continuous improvements in design and automation of single-use mixers present future opportunities for market growth.

Key Takeaways

• Single-use mixers market to crossed USD 1.73 billion by 2025.
• Market projected at USD 3.6 billion by 2034.
• CAGR of 8.54% expected in between 2024 to 2034.
• North America held a major revenue share of approximately 39% the market in 2024.
• Asia-Pacific is expected to grow at the fastest CAGR in the market during the forecast period.
• By product type, the consumables & accessories segment dominated the single-use mixers market 55% with a revenue of approximately in 2024.
• By product type, the mixing systems segment is expected to witness the fastest growth in the market over the forecast period.
• By mixing capacity/volume range insights, the 500 L-1000 L segment accounted for the highest revenue share of approximately 35% of the market in 2024.
• By mixing capacity/volume range insights, the 1000 L segment is expected to expand rapidly in the market in the coming years.
• By application, the buffer preparation segment held the largest revenue share of approximately 38% of the market in 2024.
• By application, the product mixing & final formulation segment is expected to grow at the fastest CAGR in the single-use mixers market during the forecast period.
• By mixing technology, the mechanical agitation segment contributed the biggest revenue share of approximately 45% of the market in 2024.
• By mixing technology, the magnetic stirring systems segment is expected to grow with the highest CAGR in the market during the studied years.

Executive Summary Table

The Single-Use Revolution in Biotech: Long-Lasting Impact

The single-use mixers market is experiencing robust growth, driven by growing demand for biopharmaceuticals, the increasing need for sterile biomanufacturing processes, and technological innovations in single-use mixers. It comprises disposable mixing systems, components, and accessories used for the preparation, blending, and homogenization of liquids in biopharmaceutical and bioprocessing applications.

These systems replace traditional stainless-steel mixers with pre-sterilized, single-use polymeric assemblies, minimizing cleaning validation, cross-contamination risk, and downtime. They are critical in biologics production, vaccines, cell & gene therapies, and buffer/media preparation, enabling rapid changeovers, scalable production, and compliance with cGMP and PAT guidelines.

Single-Use Mixers Market Outlook

• Industry Growth Overview: The market is expected to accelerate between 2025 and 2030, with the rapidly expanding biomanufacturing infrastructure, especially in low- and middle-income countries. Manufacturers are considering replacing traditional reusable mixers with single-use mixers due to the latter’s superior advantages.
• Global Expansion: Key players develop innovative single-use mixers to address challenges faced by customers. They deliver these products to a larger consumer base across diverse geographical locations, strengthening their market position.
• Major Investors: Private equity firms and venture capitalists provide funding to biopharmaceutical startups, enabling them to leverage advanced single-use mixers. MilliporeSigma and Cytiva Life Sciences have recently invested to expand their biologics manufacturing capabilities.

Automated Single-Use Mixers: Precision at Every Spin

AI and machine learning (ML) algorithms can help researchers and manufacturers to design innovative single-use mixers based on specific product requirements. This offers an ergonomic and efficient use experience for biomanufacturing applications. AI and ML introduce automation in single-use mixers, enhancing their efficiency, accuracy, precision, and reproducibility. They can also monitor real-time conditions of the system, allowing manufacturers to control biomanufacturing specifications.

Thermo Fisher Scientific offers the HyPerforma Mixer Touchscreen Console that can enhance upstream and downstream processes by offering advanced sensor monitoring and user-defined automated mixing recipes.

Segmental Insights

Product Type Insights

Which Product Type Segment Dominated the Single-Use Mixers Market?

The consumables & accessories segment held a dominant presence in the market in 2024, with a revenue of approximately 55% due to their easy availability and cost-effectiveness. Key players offer preconfigured and customizable consumables and accessories for their mixing systems, eliminating the need for manufacturers to purchase the entire equipment.

The mixing bags sub-segment held the largest revenue share, due to the need for small-scale compounding and mixing. 2D and 3D mixing bags are used for robust mixing of powders and liquids from discovery to commercial scale.

Mixing Systems

The mixing systems segment is expected to grow at the fastest CAGR in the market during the forecast period, due to advances in mixing systems and the need for consistency throughout the mixtures. Mixing systems lead to process efficiency, leading to higher production and reduced costs.

The top-entry mixers sub-segment is expected to grow rapidly. Top-entry mixers are more sustainable due to lower energy consumption. They require 3 to 5 times less energy than side-entry mixers. They have reduced maintenance and high mixing efficiency.

Mixing Capacity/Volume Range Insights

How the 500 L-1000 L Segment Dominated the Single-Use Mixers Market?

The 500 L-1000 L segment contributed the biggest revenue share of the market in 2024, with a revenue of approximately 35% due to the need for large-scale production of biologics. Single-use mixers with 500 L to 1000 L capacities are widely used for scaling up upstream and downstream processes after pilot scale. Mid-scale production bridges the gap between pilot scale and commercial scale, ensuring consistent manufacture of experimental formulations.

1000 L

The 1000 L segment is expected to grow with the highest CAGR in the market during the studied years. 1000 L mixers are predominantly used in commercial-scale manufacturing to produce large quantities of biologics. This enables manufacturers to deliver the products, fulfilling patients’ needs.

100 L-500 L

The 100 L-500 L segment is expected to grow in the coming years, due to the growing need for pilot-scale production to investigate and optimize product and process. Pilot scale provides valuable insights into product and process development on a larger scale. It helps identify any potential issues that may arise during mass production.

Application Insights

Why Did the Buffer Preparation Segment Dominate the Single-Use Mixers Market?

The buffer preparation segment held a major revenue share of approximately 38% of the market in 2024, due to the ability of buffers to maintain and optimize a stable pH throughout the manufacturing process. Single-use mixers are specifically designed to enable the mixing of media, buffers, and other process liquids, facilitating optimal performance. Buffer solutions are particularly essential for activities like enzymatic reactions, cell cultures, and protein purifications.

Product Mixing & Final Formulation

The product mixing & final formulation segment is expected to expand rapidly in the market in the coming years. Single-use mixers are essential for mixing and preparing the final formulation of biologics. They offer a flexible and sterile system for preparing final products. The risk of cross-contamination also reduces with single-use mixers.

Intermediate Processing

The intermediate processing segment is expected to grow in the upcoming years. Intermediate processing is a critical step in the chemical pathway that leads to the production of API. Intermediate processing includes harvest and clarification steps and concentration/dilution of protein solutions.

Mixing Technology Insights

What Made Mechanical Agitation the Dominant Segment in the Single-Use Mixers Market?

The mechanical agitation segment led the market in 2024, due to high-intensity mixing and customized speed control ability. Mechanical agitation refers to devices, like mixers and agitators, to achieve uniformity and desired reactions. It allows the formation of stable formulations, such as suspensions and emulsions, as well as appropriate heat transfer in the system.

Magnetic Stirring Systems

The magnetic stirring systems segment is expected to witness the fastest growth in the market over the forecast period. The demand for magnetic stirring systems is increasing, as they provide contact-free mixing, avoiding equipment contamination. In addition, magnetic systems possess a lesser chance of rusting or corrosion.

Rocking Motion/Wave-Type

The rocking motion/wave-type segment is expected to grow in the coming years. Wave-type mixing uses a rocking platform to oscillate a disposable bag, thereby creating waves in the fluid for mixing and gas transfer. These waves are generated through an electric system and impose lower stress values in the liquid medium during agitation.

Regional Analysis

Which Factors Contribute to the Single-Use Mixers Market in North America?

North America dominated the market with approximately 39% share in 2024. The region has a strong presence of biopharmaceutical and biotech companies that are strongly dedicated to producing innovative biologics. Favorable regulatory support and the increasing adoption of advanced technologies foster market growth. The availability of state-of-the-art research and development facilities also propels the market.

From Labs to Leadership: U.S. Biotech at its Peak

Key players, such as Thermo Fisher Scientific, Meissner Corporation, and Cytiva Life Sciences, provide high-quality and customized single-use mixers in the U.S. The U.S. is home to more than 3,028 biotech companies as of 2024, representing an increase of 4.2% from 2023. The U.S. government is committed to growing the bioeconomy by investing $46 billion in public and private sector biomanufacturing.

How is Asia-Pacific Growing in the Single-Use Mixers Market?

Asia-Pacific is expected to host the fastest-growing market in the coming years. Countries like China, India, and Japan have well-established biomanufacturing infrastructures and an affordable workforce, encouraging foreign investors to set up their manufacturing facilities in these countries. Government and private organizations provide funding for the adoption of single-use technologies for large-scale biologics production. The growing geriatric population necessitates manufacturers to fulfill unmet patient needs, favoring large-scale production of biologics.

China: Emerging Biotech Growth

China has been emerging as a global biotech hub for several decades by expanding biomanufacturing capacity and attracting venture capital investments. The Chinese biotech sector attracted approximately CNY 20 billion (EUR 2.6 billion) in public funding in 2023. China’s innovation capabilities have surpassed Europe in most biotech areas, and the U.S. in some. According to a recent BIO survey, 79% of 124 global biopharma companies have at least one contract or product with a China-based CDMO/CMO.

Will Europe Shine in the Single-Use Mixers Market?

Europe is expected to grow at a considerable CAGR in the market in the upcoming period. Favorable government support for the development and manufacturing of biologics boosts the market. Government and private institutions conduct seminars and workshops to share the latest updates about innovative biomanufacturing technologies. Advancements in digital monitoring and sustainable materials also contribute to market growth.

Germany: Rise of Single-Use Technologies

Germany hosted the 5th BIOTECH Conference 2025 – Single-Use Technologies for Bio-Based Applications to focus on areas such as bioprocess development and manufacture with single-use technology and process analytical technologies for single-use devices. Companies like Sartorius AG and Merck Group, headquartered in Germany, provide single-use mixers to global biotech companies.

Evolving Regulatory Landscape to Drive South America

South America is considered to be a significantly growing area in the single-use mixers market. The burgeoning biopharma sector and the growing demand for personalized medicines potentiate the need for single-use mixers. Manufacturers are aware of the benefits of single-use mixers over traditional mixers. Efforts are made to strengthen policy and regulatory frameworks to encourage innovation and safe adoption of new biotechnologies.

Brazil: Blending Innovation in Bioprocessing

Brazil’s single-use mixers market is thriving, fueled by expanding biopharma manufacturing, sustainability initiatives, and flexible production demands. Local biotech investments and government-backed healthcare modernization accelerate adoption across research and production facilities.

UAE: Stirring Growth in Smart Manufacturing

The UAE is rapidly embracing single-use mixers, driven by its vision for advanced healthcare, biotech innovation, and clean manufacturing. Strategic partnerships and smart facility expansions strengthen its regional bioprocessing capabilities.

Bioprocessing Expansion in the Middle East & Africa

The Middle East & Africa are expected to grow at a notable CAGR in the foreseeable future. The increasing number of biotech startups and venture capital investments in the region facilitates the development and use of single-use mixers. Government organizations launch initiatives to support the indigenous development of biologics. Countries like the UAE, South Africa, and Saudi Arabia are actively investing in R&D, biomanufacturing, and genomics.

Company Landscape

Sartorius AG

Company Overview

A global life-science and lab-equipment supplier focused on biopharmaceutical manufacturing, including single-use systems and mixers.

Corporate Information

• Headquarters: Göttingen, Germany. | Year Founded: 1870. | Ownership Type: Public (Aktiengesellschaft).

History and Background

Founded in 1870 as a precision instrument maker, evolved into a major bioprocess-solutions provider with strong growth in single-use technologies.

Key Milestones / Timeline

• Launch of its “Flexsafe®” single-use mixer portfolio for low-shear / rapid mixing.
• Announced in 2025 a production expansion in France: new GMP facility for raw materials/components for cell & gene therapies (>8,000 m²).

Business Overview

• Business Segments / Divisions: Bioprocess Solutions (fluid management, single-use, mixers) and Lab Products & Services.
• Geographic Presence: Worldwide, strong in Europe, North America, and Asia-Pacific; production sites in Germany, France, and others.
• Key Offerings: Single-use mixers, mixing bags & consumables, other bioprocess equipment.
• End-Use Industries Served: Biopharmaceutical manufacturers (upstream/downstream bioprocessing), cell & gene therapy, vaccine manufacturing.

Key Developments and Strategic Initiatives

• Mergers & Acquisitions: The company has grown via acquisitions of complementary technologies.
• Partnerships & Collaborations: Investment in cell & gene therapy infrastructure shows strategic direction.
• Product Launches / Innovations: Flexsafe® Pro Mixer introduced as an ease-of-use mixing system.
• Capacity Expansions / Investments: The French facility expansion (2025) adds manufacturing & GMP supply capacity.
• Regulatory Approvals: While specific mixer approvals aren’t widely publicized, the single-use systems are designed for GMP compliance.
• Distribution Channel Strategy: Global manufacturing + support network, selling to biopharma and CDMO customers.
• Technological Capabilities / R&D Focus: Focus on low-shear and high-performance mixing, inline sensors (pH, conductivity, temperature) in single-use mixers.
• Core Technologies / Patents: Levitating impeller design, inline monitoring for single-use mixers.
• Research & Development Infrastructure: Web resources indicate CFD modeling of mixing performance, internal R&D in single-use platforms.
• Innovation Focus Areas: Scalability, modular single-use mixing systems, improved analytics, and process-control for biomanufacturing.

Competitive Positioning

• Strengths & Differentiators: Deep expertise in single-use bioprocessing, robust global supply chain, strong innovation in mixing technology (e.g., levitating impeller, low-shear design), and credibility in GMP contexts.
• Market presence & ecosystem role: Recognized in industry reports as a top player dominating the single-use mixers market alongside others.

SWOT Analysis:

• Strengths: Strong brand, broad product portfolio, global footprint.
• Weaknesses: High cost of advanced single-use systems, reliance on biopharma capital investment.
• Opportunities: Growth in cell & gene therapy, rising demand for single-use mixers in emerging markets.
• Threats: Alternative technologies, regulatory shifts, supply‐chain disruptions.
• Recent News and Updates: Facility expansion in France (Sept 2025) to support cell & gene therapies.
• Press Releases: The above expansion was communicated via the company media.

Thermo Fisher Scientific, Inc.

Company Overview

A global leader in life-science tools, lab instruments, consumables, and bioprocessing equipment, including single-use mixers for upstream/downstream manufacturing. 
Corporate Information

• Headquarters: Waltham, Massachusetts, USA. |  Year Founded: 1956 (as Thermo Electron, merged with Fisher Scientific in 2006). | Ownership Type: Public.

History and Background

Formed via the merger of Thermo Electron and Fisher Scientific in 2006, expanded through acquisitions, and provides a broad spectrum of life-sciences solutions; single-use mixing systems are part of its bioprocessing portfolio.

Key Milestones / Timeline

• Introduced HyPerforma Single-Use Mixer DS 300 system for pilot-scale liquid preparation (historical).
• In 2025, Oct announced the acquisition of a digital health/clinical trials platform to expand drug-development services.

Business Overview

• Business Segments / Divisions: Life Sciences Solutions, Analytical Instruments, Specialty Diagnostics, Biopharma Services & Manufacturing Solutions; within bioprocessing, offers single-use mixing equipment and consumables.
• Geographic Presence: Global, with strong U.S., Europe, Asia operations, manufacturing, and services network.
• Key Offerings: Comprehensive portfolio of single-use mixers (HyPerforma, imPULSE, Mixtainer systems) supporting volumes from 10 L to 5,000 L.
• End-Use Industries Served: Biopharmaceutical manufacturing (upstream & downstream), vaccine production, contract manufacturing organizations (CDMOs), research laboratories.

Key Developments and Strategic Initiatives

• Partnerships & Collaborations: Broad, e.g., strategic collaboration with AI/analytical or digital health (2025 acquisition of Clario data-management firm).
• Product Launches / Innovations: Single-use mixers portfolio launched/upgraded (e.g., HyPerforma S.U.M., imPULSE) supporting large-scale mixing.
• Capacity Expansions / Investments: Announced in 2021-22 new manufacturing site (Nashville) to more than double its single-use technology manufacturing capacity.
• Regulatory Approvals: Single-use mixers designed for cGMP compliance; general compliance documented.
• Distribution Channel Strategy: Global manufacturing + service footprint, sells directly and via distributors, supports major biopharma and CDMOs.
• Technological Capabilities / R&D Focus: Mixers engineered for both liquid/liquid and powder/liquid mixing, high and low shear applications, support scale-up to 5,000 L.
• Core Technologies / Patents: Drive systems, sealed single‐use containers, modular mixing solutions.
• Research & Development Infrastructure: Extensive global R&D in life sciences and bioprocessing; expansion of manufacturing and innovation sites.
• Innovation Focus Areas: Closed single‐use mixing systems, integration with automation and sensors, biobased consumables for reduced carbon footprint.

Competitive Positioning

• Strengths & Differentiators: Strong brand and global scale, deep bioprocessing product portfolio, high manufacturing capacity for single‐use technologies, ability to support large‐volume mixing up to 5,000 L.
• Market presence & ecosystem role: Identified in market research as one of the leading vendors for single-use mixers.

SWOT Analysis:

• Strengths: Global reach, broad portfolio, manufacturing scale.
• Weaknesses: Complexity of integration across many product lines, high cost.
• Opportunities: Growth in biologics, vaccines, cell & gene therapy, expansion in emerging markets.
• Threats: Volatile macroeconomics, supplier constraints, regulatory/regime change.

Recent News and Updates:

• Announced acquisition of Clario (data management for clinical trials) up to $9.4 billion in cash/future payments (Oct 2025).
• Announced purchase of Solventum’s purification & filtration business for ~US$4.1 billion (Feb 2025) to enhance bioprocessing capabilities.

Top Companies & Their Offerings in the Single-Use Mixers Market

Other Companies

• Eppendorf AG
• Saint-Gobain Performance Plastics
• PBS Biotech, Inc.
• Meissner Filtration Products, Inc.
• Agilitech
• DrM Life Science (Dr. Müller AG)
• Novasep Holding S.A.S.
• FlexBiosys Inc.

Recent Developments in the Single-Use Mixers Market

• In September 2024, Merck announced the launch of the Mobius single-use reactor specifically designed to manufacture antibody drug conjugates (ADCs). The mixer is tailored to meet the unique requirements, offering faster turnaround times and fewer cross-contamination risks.
• In April 2024, Cytiva Life Sciences launched Xcellerex magnetic mixer to address challenges related to large-scale monoclonal antibody, vaccine, and genomic medicine manufacturing processes. The mixer is available in 2000 and 3000 L capacities and aids in buffer and cell culture media.

Segments Covered in the Report

By Product Type

• Mixing Systems
• Top-entry Mixers (Impeller-based)
• Bottom-entry Magnetic Drive Mixers
• Orbital/Rocking Motion Mixers
• In-line/Static Single-Use Mixers
• Consumables & Accessories
• Mixing Bags (2D/3D Disposable Bags)
• Tubing Sets & Sterile Connectors
• Sensors & Probes (pH, DO, Temperature)
• Support Hardware (holders, frames, motor drives)

By Mixing Capacity/Volume Range

• <100 L (laboratory & small-scale R&D)
• 100 L-500 L (pilot & process development)
• 500 L-1000 L (mid-scale production)
• 1000 L (commercial biomanufacturing)

By Application

• Buffer Preparation
• pH-adjusted process buffers
• Cleaning and neutralization buffers
• Media Preparation
• Cell culture media hydration
• Nutrient and additive blending
• Product Mixing & Final Formulation
• Drug substance formulation
• Adjuvant blending (vaccines)
• Intermediate Processing
• Harvest and clarification steps
• Concentrate/dilution of protein solutions

By Mixing Technology

• Mechanical Agitation
• Impeller-driven top & bottom entry
• Magnetic Stirring
• Magnetically coupled impellers (contact-free)
• Rocking Motion/Wave-type
• Pneumatic/orbital movement mixers
• Static/In-line Mixing
• Disposable static mixers for continuous systems

By Region

• North America
  • US
  • Canada
  • Mexico
  • Rest of North America
• South America
  • Brazil
  • Argentina
  • Rest of South America
• Europe
  • Western Europe
    • Germany
    • Italy
    • France
    • Netherlands
    • Spain
    • Portugal
    • Belgium
    • Ireland
    • UK
    • Iceland
    • Switzerland
    • Poland
    • Rest of Western Europe
• Eastern Europe
  • Austria
  • Russia & Belarus
  • Turkiye
  • Albania
  • Rest of Eastern Europe
• Asia Pacific (APAC)
  • China
  • Taiwan
  • India
  • Japan
  • Australia & New Zealand
  • ASEAN Countries (Singapore, Malaysia)
  • South Korea
  • Rest of APAC
• Middle East and Africa (MEA)
  • GCC Countries
    • Saudi Arabia
    • United Arab Emirates (UAE)
    • Qatar
    • Kuwait
    • Oman
    • Bahrain
  • South Africa
  • Egypt
  • Rest of MEA