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Seamless and Lilly into a Seamless Agreement to Loud their Research Game

Seamless Therapeutics has entered a major licensing agreement with Eli Lilly to accelerate the development of programmable recombinase-based gene-editing therapies for genetic hearing loss.

Category: Business Published Date: 2 March 2026
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Introduction

Seamless Therapeutics, a well-known biotechnology company  operates its exclusive programmable recombinase platform to upgrade and modernise gene editing. Since the company came into the limelight due to a Technical University of Dresden spin-off, it has always concentrated on discovering innovations and treatments for extreme genetic diseases. But this modernised healthcare era motivated the company to showcase its expertise in advanced gene editing. The popular Seamless’s enzymes are pretty well designed to elevate and improve DNA fragments.

Announcement

Seamless cracked a deal with the star Eli Lilly and Company to accelerate the research line, later establish and marketise its programmable recombinase-related treatments, aiming at hearing loss conditions. The Seamless’s exclusive recombinase platform will play a fundamental role to bring mission into action. This partnership stands on the confidence of Seamless’s impeccable technology, which covers huge, appropriate DNA insertions in any of the gene sequences on demand and works impromptu throughout the cell’s natural DNA repair.

Terms and Conditions

According to this licensing agreement, Seamless will engineer and operate a particular site-based recombinase registered to fix the mutations in hearing loss-based genes. On the other hand, Lilly will get the authority to legally use programmed recombinases in its clinical and preclinical drug development and marketise it at a larger platform within the company’s set boundaries.

The transaction inflow and outflow confirm that Seamless will get fixed research and development money and a promised upfront payment. Seamless will receive a total of $1.12 billion involving marketing (sales) profit and worthy development payments. Seamless will not receive any tiered royalties as per the deal. Further, the additional insight of this agreement has not yet updated. These promises will strengthen Seamless’s finances and promote its offerings at the core, visible in Lilly’s advancements and future endeavours. With these confirmations, the companies locked the deal.

Chief Executive Officer at Seamless Therapeutics, PhD, Albert Seymour, said, “Lilly is the investor of genetic disease treatment approaches, and we relate to Lilly’s strong vision of introducing genetic medicines for those patients who have no good number of treatment options. We’re also excited to work with our partners at Lilly to fulfil this joint goal of transitioning the genetic hearing loss patients’ results.”
“We see it as a commendable opportunity to prove our technology’s potential in treatments and to extend the therapeutic strength for programmable recombinases via our excellent pipeline.”

Author

Chandni Pathak

Chandni Pathak

Holding M.Pharm in Pharmaceutical Chemistry, Chandni crafts cutting-edge, research-driven healthcare news for Towards Healthcare, combining scientific depth with innovative storytelling to simplify complex topics for global readers.