Towards Healthcare

AN2 and GSK into a research partnership focusing on TB

AN2 Therapeutics partners with GSK and Gates Foundation to develop new tuberculosis (TB) therapies using boron chemistry for better patient outcomes.

Category: Science Published Date: 13 November 2025
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Announcement

AN2 Therapeutics, Inc., a leading biopharmaceutical company specialising in small molecule therapeutics with its comprehensive boron chemistry platform, has fixed a research collaboration deal with the leading GSK biopharma company to discover new therapies for tuberculosis (TB). TB has been the most common yet largely found condition in many individuals. TB has consistently been a key global health challenge, disturbing a quarter of the population globally and has registered 1.25 million deaths yearly.

To participate in this initiative, the Gates Foundation will offer a third year of funding to contribute to AN2’s efforts within this partnership act. Alongside this discovery, the existing LeuRS is also a same examined focus specifying epetraborole apt in development for NTM lung disease, tavaborole and ganfeborole for development for TB are FDA-approved antifungal.

The partnership involves strong-headed leaders running excellence on their own shoulders, along with a smart team, and the support from the private American Gates Foundation speaks to the depth of the importance this condition holds. AN2’s pipeline and boron chemistry platform integration to the GSK potential will fuel growth and development in the vast healthcare market.

The partnership between the leading companies has always led to fruitful advancements and commendable solutions, improving the health of patients facing challenging conditions in regions with no such advancements and availability.

Statements from the healthcare leaders

Chairman, President, Co-Founder, and CEO of AN2 Therapeutics, Eric Easom, said, “Our boron chemistry platform provides a classified and evident idea to small molecule drug discovery, making a way for capable breakthroughs in identifying the highest requirement in other therapeutic areas and infectious diseases. The Boron chemistry has allowed the design of compounds that sharpen the aim on novel mechanisms like LeuRS. LeuRS is not achieved by old carbon-related chemistry ideas.”

Easom added, “We think it can serve as an effective therapy in infectious diseases such as TB and nontuberculous mycobacterial (NTM) lung disease. Including different therapeutic areas involving crucial solid-tumor oncology targets like ENPP1 and PI3Kα, and other important targets.”

Chief Global Health Officer of GSK, Thomas Breuer, said, “To lead in accurate treatment for the deadliest infectious disease, tuberculosis needs robust collaboration and bold science. With this partnership with AN2 Therapeutics, backed by the Gates Foundation, we feel grateful to advance innovative approaches to seek the establishment of the new TB treatments for the area covering population with lower income.”

Author

Mansi Kadam

Mansi Kadam

Mansi Kadam is a market research writer with over 3 years of experience analyzing trends in the healthcare industry. At Towards Healthcare, she covers innovations in medical sector, sustainability initiatives, and the evolving regulatory landscape.