U.S. Longevity & General Wellness Supplements Market Outlook Ahead

Revenue, 2025

USD 6.38 Billion

Forecast, 2035

USD 11.53 Billion

CAGR, 2026-2035

6.1%

Report Coverage

Global

U.S. Longevity & General Wellness Supplements Market Size, Key Players and Growth with Shares

The U.S. longevity & general wellness supplements market size is expected to be worth around USD 11.53 Billion by 2035, from USD 6.38 billion in 2025, growing at a CAGR of 6.1% during the forecast period from 2026 to 2035.

The U.S. longevity & general wellness supplements market is experiencing robust growth, driven by growing research and development activities, shifting trend towards nutraceuticals, and increasing awareness of health & wellness. People are becoming increasingly aware of cellular health and, therefore, take necessary measures to promote healthy aging. Technological advancements, such as wearable devices, help patients keep track of their vital signs continuously.

Key Takeaways

• U.S. longevity & general wellness supplements market to crossed USD 6.77 billion by 2026.
• Market projected at USD 11.53 billion by 2035.
• CAGR of 6.1% expected in between 2026 to 2035.
• By application, the general wellness supplement segment dominated the U.S. longevity and wellness supplements market in 2025.
• By application, the longevity supplements segment is expected to grow at the fastest CAGR during the forecast period.

Executive Summary Table

The Science of Aging Well Through Supplements

The U.S. longevity & general wellness supplements market encompasses the curation, production, and distribution of supplements to support longevity and wellness among individuals. These supplements range from antioxidant-rich botanicals to advanced nutraceutical blends to support healthy aging, cellular vitality, and overall wellness. Some common examples of supplements include creatine, curcumin, magnesium, resveratrol, taurine, and vitamin D.

Redefining Healthspan: AI-Driven Innovation in U.S. Wellness

Artificial intelligence (AI) and machine learning (ML) algorithms provide unprecedented tools for analyzing complex biological data and suggesting measures to promote healthy aging. They monitor the calories and food intake of individuals, enabling them to make necessary changes. They also aid researchers in developing personalized medicines based on their biological conditions. AI-based robotics and automated monitoring systems significantly improve elderly care, lifestyle interventions, and clinical trials, demonstrating the potential to extend both healthspan and lifespan.

Trends & Future Outlook in the U.S. Longevity & General Wellness Supplements Market

• Growing Awareness: The growing awareness of cellular health, healthy aging, and biohacking potentiates the demand for supplements derived from natural sources.
• Increasing Research Activities: Researchers aim to develop and identify supplements for expanded, novel applications and also determine their doses.
• Wearable Devices: Wearable devices continuously monitor vital signs, such as heart rate, calorie intake, and footsteps, to meet personalized daily targets.

Investment Landscape Supporting Longevity & Wellness

• In March 2025, Herbalife Ltd. acquired a 100% stake in Pro2col Health LLC and Pruvit Ventures, Inc., as well as a 51% controlling stake in Link Biosciences, Inc. The investment was made to modernize Herbalife’s business and strengthen its position as the world’s premier health and wellness company, community, and platform.
• In January 2025, Hone Health raised $33 million in a Series A funding round to expand its services into proactive and preventive longevity care for men and women while supporting its commitment to regulatory compliance and patient safety.
• In November 2024, OneSkin announced the closure of its Series A funding round, bringing the total funding of the brand to $20 million, to support the development of its patented peptide, OS-01, to prevent the accumulation of senescent cells.

Segmental Insights

Application Insights

Which Application Segment Dominated the U.S. Longevity & General Wellness Supplements Market?

The general wellness supplements segment held a dominant position in the market in 2025, due to the growing demand for preventive health. Certain government and private bodies conduct wellness programs to reduce elevated health risks like blood pressure, glucose, and cholesterol. Focusing on general wellness enables individuals to augment lifespan, boost immune function, and improve mental health. It is estimated that approximately 55% of Americans are regular users of dietary supplements.

Longevity Supplements

The longevity supplements segment is expected to grow at the fastest CAGR in the market during the forecast period. The growing awareness of enhancing life expectancy among the general public boosts the segment’s growth. According to the Centers for Disease Control and Prevention (CDC), the average life expectancy rate of Americans is 78.4 years. Thus, people rely on supplements to increase longevity. Numerous studies have demonstrated the role of multivitamins and mineral supplements in longevity.

Geographical Analysis

Which Factors Govern the U.S. Longevity & General Wellness Supplements Market?

The increasing need for preventive health, the rising disposable income, and favorable government support are major factors that govern market growth in the U.S. The region has a well-established clinical trial infrastructure, enabling researchers to assess the biological role of supplements on humans. As of 8th January 2025, 5 trials related to longevity supplements and 19 trials related to general wellness supplements were registered in the U.S.

The U.S. government has launched the “Healthy People 2030” initiative to improve health and well-being over the next decade. Moreover, Gen Zs and millennials account for over one-third (36%) of the total adult population in the U.S., driving more than 41% of annual wellness spend, primarily due to the burgeoning prioritization of wellness. According to a McKinsey survey on 3,700 people in November 2024, more than 30% of respondents considered aging prevention.

Value Chain Analysis – U.S. Longevity & General Wellness Supplements Market

R&D

• The latest research focuses on determining the long-term potential of supplements on human health and developing novel drug delivery systems.
• Key Players: Life Extension, Elysium Health, and Decode Age

Clinical Trials

• Trials assess the safety and efficacy of natural supplements on humans and identify their mechanism of action.
• Key Players: Citruslabs, Longevity Pharmaceuticals, and AgeX Therapeutics.

Patient Support & Services

Patient support & services refer to conducting wellness programs to promote awareness of functional medicine practices.

Top Companies & Their Offerings in the U.S. Longevity & General Wellness Supplements Market

SWOT Analysis in the U.S. Longevity & General Wellness Supplements Market

Strengths

• People prefer nutraceuticals or products derived from natural sources to improve their health and well-being.
• The rising disposable incomes also facilitate the need for longevity & wellness supplements to prevent future chronic illnesses and healthcare costs.
• Certain natural products show promising outcomes in extensive research and human trials.

Weaknesses

• People have a common misbelief that natural products are relatively harmless. However, some supplements may pose significant health threats that outweigh their benefits.
• High doses of supplements pose a high risk of interacting with medications or causing liver toxicity.

Opportunities

• AI-powered platforms can assess an individual’s height, weight, age, lifestyle, and health goals to identify micronutrient imbalances and deliver nutritional insights.
• The burgeoning e-commerce sector enhances the accessibility of supplements across diverse geographical locations.
• The growing demand for personalized nutrition and a healthy lifestyle also presents future opportunities for market growth.

Threats

• Several supplements lack sufficient scientific data tested on humans. They mostly rely on early-stage research, often conducted on animals.
• The FDA does not authorize wellness supplements, and hence, acts as an obstacle to the commercialization of promising interventions.

Recent Developments in the U.S. Longevity & General Wellness Supplements Market

• In September 2025, Joi + Blokes announced the launch of its Smart Supplement program to personalize daily supplementation using real-time symptom data and clinical-grade biomarkers. The program offers three pathways, including build-your-own-pack, symptom-based quiz, and labs + clinician review.
• In May 2025, researchers from Augusta University reported positive results from its clinical trial assessing vitamin D3 supplements to help slow down the cellular aging process. Vitamin D3 could prevent the equivalent of nearly three years of aging compared to the placebo by protecting telomeres.

Segments Covered in the Report

By Application

• General Wellness Supplements
  • Type
  • Vitamins
  • Multivitamins
  • Individual Vitamins
  • Minerals
  • Amino Acids
  • Probiotics
  • Collagen
  • Fish Oils
  • Coenzyme Q10
  • Herbal Extracts
  • Others
• Sales Channel
  • Online
    • Direct-to-Consumer
    • Other e-commerce channels
  • Offline
    • Hypermarkets/Supermarkets
    • Pharmacies & Drug Stores
    • Others
• Longevity Supplements
  • Type
    • NMN
    • NR
    • NAD+
    • NADH
    • Resveratrol
    • Fisetin
    • Quercetin
    • Cucurmin
    • Collagen
    • Pterostilbene
    • Others
• Sales Channel
  • Online
    • Direct-to-Consumer
    • Other e-commerce channels
  • Offline
    • Hypermarkets/Supermarkets
    • Pharmacies & Drug Stores
    • Others