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Roche’s Phase 2 results made a worthy contribution in CT-388

Roche’s CT-388 is a new obesity drug showing strong weight loss results in Phase 2 trials. It may compete with leading GLP-1 weight loss treatments.

Category: Science Published Date: 30 January 2026
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Introduction

Roche Company is a diagnostics and pharmaceuticals champion straight from the Swiss land. The company has marked its position in the healthcare sector for its personalised solutions, mainly in the oncology field. A huge biotech company, Roche, is known for merging diagnostic tools and research in medicines to deliver the right treatment for patients with CNS disorders, immunology, and cancer.

Since 1896, Roche’s groundbreaking science-inspired solutions have been innovative and impressive, which not only provide access to medicines but also polish its innovations via its effective branches.

Announcement

Roche’s Phase 2 results harnessed the CT-388 upgradation, indicating that the weight loss convincing results can be considered/referred to form a data for upgrading CT-388. The company’s duo GLP-1/GIP receptor agonist achieved a convenient response of the drug that called for new competition against Eli Lilly’s legacy of obesity and turns out to be an asset, a plus point for late-stage testing.

William Blair’s analysts were confident enough to give a statement that Roche’s CT-388 is competitive with Eli Lilly’s Zepbound. Though the whole testing and clinical procedure is yet to be proved, the obesity leaders and analyst are raising their thoughts with either confidence, hope or business motive. With this, Roche’s efforts phrase that the successful result can bring new solutions into frame, either being a part or a whole to different clinical trials and more through practice and dedication.

Results origin

The Phase 2 trial of CT-388 results came to light in 2023 during the acquisition of Carmot Therapeutics. The CT-388 injectable brought placebo-balanced weight loss to 22.5% progress at 48 weeks alone, excluding the weight loss plateau. In this trial, around 95% patients succeeded in weight loss by 5% at 48 weeks, and fortunately, 30% of weight loss was achieved in a quarter of the population.

The patient group having pre-diabetes also participated in this trial and witnessed a general blood glucose level settling at 48 weeks, which is more satisfying than those in the placebo group.

Efforts for CT-388

The company, after signing the acquisition deal with Carmot, took control of the obesity pipeline and CT-388, further immediately elevating the development phase of the same. After this, CT-388 confirmed its position as a fast-track molecule in robust pharma’s pipeline. The expectations from CT-388 are high in the obesity field, as there may be a stream of obesity molecules in the near future.

Author

Mansi Kadam

Mansi Kadam

Mansi Kadam is a market research writer with over 3 years of experience analyzing trends in the healthcare industry. At Towards Healthcare, she covers innovations in medical sector, sustainability initiatives, and the evolving regulatory landscape.