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Organoids and Spheroids Market Size | Companies Report by 2033

Organoids and Spheroids Market Size (USD 6,450.55 Mn) by 2033

The report covers Organoids and Spheroids Market Manufacturers such as Thermo Fisher Scientific, Inc., STEMCELL Technologies Inc., Prellis Biologics, Merck KGaA, Lonza, InSphero, Hubrecht Organoid Technology (HUB), Greiner Bio-One, Corning Incorporated, Cellesce Ltd., AMS Biotechnology (Europe) Limited, 3D Biotek LLC and 3D Biomatrix. The report offers the value (in USD Million) for the segments.

Organoids and Spheroids Market Size, Stats and Growth Report

The organoids and spheroids market size reached US$ 805.3 million in 2023 and is expected to hit US$ 6,450.55 million by 2033. It is poised to grow at a CAGR of 23.13% from 2024 to 2033. Advances in genome editing technologies, automation, microfluidics, stem cell research, and microfluidics are driving substantial innovation in the sector.

Organoids and Spheroids Market Revenue 2023 - 2033

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Key Takeaways

  • North America led the market with the largest revenue share of 43% in 2023.
  • By type, the spheroids segment has generated more than 54% of revenue share in 2023.
  • By type, the organoids segment is expected to grow at the fastest rate during the forecast period.
  • By application, the developmental biology segment has held the largest revenue share of 31% in 2023.
  • By application, the regenerative medicine segment is anticipated to grow at the fastest rate during the forecast period.

Industry at a Glance

The organoids and spheroids market encompasses the use of organoids and spheroids for various purposes, such as research and development, the study of different diseases, the development of personalized medicines, and so on. Spheroids, which can be seen in tumor tissue, embryoid bodies, hepatocytes, neurological tissue, or mammary glands, are basic clusters of widely distributed cells. Organoids are intricate collections of cells that are exclusive to a particular organ, such as the bladder, liver or stomach. Organoid models are being used more often to investigate and uncover the mechanism of the COVID-19 virus, which affects several intestinal cells, as a result of the recent coronavirus outbreak. Many scientists are already using these methods to evaluate and identify potential new drugs. Additionally, businesses involved in product development and launch are becoming more active in this field. The expansion of organoids and spheroids market has been driven by a wide range of applications.

Top Companies in the Organoids and Spheroids Market

  • Thermo Fisher Scientific, Inc.
  • STEMCELL Technologies Inc.
  • Prellis Biologics
  • Merck KGaA
  • Lonza
  • InSphero
  • Hubrecht Organoid Technology (HUB)
  • Greiner Bio-One
  • Corning Incorporated
  • Cellesce Ltd.
  • AMS Biotechnology (Europe) Limited
  • 3D Biotek LLC
  • 3D Biomatrix

Merck KGaA Pipeline in the Organoids and Spheroids Market

Company Name Merch KGaA
Headquarters Darmstadt, Germany
Research & Development Costs (2023) Healthcare: € 1,657 million
Life Science: € 396 million
Pipeline This next generation of organoids based on chip technology is now being investigated by the firm, bringing colleagues in life science, healthcare, and electronics together to work on this innovative field, according to the company's annual report released in June 2024.

InSphero Pipeline in the Organoids and Spheroids Market

Company Name InSphero
Headquarters Schlieren, Switzerland
Pipeline In May 2024, InSphero AG is happy to announce its exclusive commercialization agreement with Frankfurt, Germany-based Genome Biologics, as a substantial extension of its industry-leading portfolio. Through this collaboration, Genome Biologics' ground-breaking 3D Cardiac Organoid Platform will be exclusively licensed for worldwide commercialization to InSphero. The accurate, scalable, and disease-specific organoid models provided by this platform, which is at the forefront of heart disease research, are essential for the creation of cutting-edge treatments.

Rising Number of Cancer Cases Demand for the Organoids and Spheroids Market

Global New Cancer Cases in 2024 - 2045

The IARC projections underscore the increasing global cancer burden, the disproportionate impact on marginalized people, and the pressing need to address cancer disparities. They are based on the best data sources available in nations in 2022. An estimated 20 million new cases and 9.7 million deaths from cancer were predicted for 2022. 53.5 million people were thought to still be alive five years after being diagnosed with cancer. In their lifetime, 1 in 5 people will have cancer; 1 in 9 men and 1 in 12 women will pass away from the illness.

Understanding human development, the onset and course of disease, and tailored medical approaches—achievements that may not be achievable with animal models—has been made feasible by the creation of spheroid and organoid models. One cutting-edge technique is the use of 3D culture, especially when researching malignancies and finding possible anticancer medications for them. Comparing spheroids and organoids to other in vitro techniques for anticancer drug screening, it has been established that they are flexible in vitro preclinical models and instruments for translatable and dependable clinical outcomes.

For instance,

  • In May 2024, NASA and experts from California have joined forces to carry the fight against cancer to space since development in this area is lagging behind Earth. the University of California, San Diego, created small tumor organoids from cancer patients' cells that were cultivated in a lab. These odd passengers were carried on board the International Space Station together with four crew members.

Necrosis in Inner Layers Restraints the Organoids and Spheroids Market Growth

The development of tissue necrosis in the inner layer of both spheroids and organoids is the extent of their usefulness and maturation as pre-clinical models and in drug testing. Large-size spheroids and organoids are most affected by this due to their avascular nature and decreased diffusion of nutrients and oxygen. Necrosis occurs when there is insufficient perfusion flow and a dysfunctional vascular network in the inner layer of spheroids and organoids. There have been attempts to get around the problem, such as the use of affordable 3D bioprinting technology. It has been demonstrated that 3D bio-printed organoids can precisely deliver gene-drug connections and more accurately mimic complicated cell physiology with carriers of signaling molecules. Organ-on-a-chip systems have been able to provide nutrients more effectively because of the application of microfluidics technology.

AI and 3D Model Technologies Drive the Organoids and Spheroids Market

Artificial intelligence (AI)- enabled organoids, which interface with AI, have the potential to completely transform the industry by providing new perspectives and approaches that help accelerate the creation and clinical use of organoids. AI-powered organoids combine AI with organoid development, accelerating new approaches. The AI interface makes multiscale picture processing, accurate preclinical evaluation, and organoid assembly possible. Acknowledging the difficulties in integrating AI with organisms can improve comprehension and streamline therapeutic implementations.

For instance,

  • In March 2024, the Terasaki Institute for Biomedical Innovation (TIBI) today announced the founding of four innovative startup firms, marking a significant milestone for the advancement of biomedicine. With these endeavors, TIBI is taking a calculated risk in its mission to innovate healthcare reform. Utilizing the institute's innovative research in tissue engineering, improved biosensing, organoids, microneedles, and biomaterials, these firms are well-positioned to address some of the most important health issues of our day. Organoid technology, artificial intelligence, high-throughput digital culture platforms, and state-of-the-art biomaterials are all being used for the first time by Digital Immunology.

Alongside AI, the development of a three-dimensional (3D) organoid culture system has been made possible by advances in our knowledge of organogenesis, stem cell niches, and disease models. In terms of comprehending the intricacies of human diseases, 3D organoid models represent a substantial technical advance that may be used for anything from the mechanistic exploration of disease causation to therapeutic intervention.

For instance,

  • In March 2024, a non-profit organization in Louisville plans to send tiny 3D representations of the human brain into space. A press statement stated that the National Stem Cell Foundation is attempting to get a deeper understanding of the neurological underpinnings of illnesses such as multiple sclerosis, Parkinson's, and Alzheimer's by sending brain organoids to the International Space Station this week.

Report Highlights

Type Insights

By type, the spheroids segment dominated the organoids and spheroids market in 2023. The spheroid culture system presents itself as a compelling means of getting around the drawbacks of conventional monolayer culture. Spheroids have significant promise for a variety of applications, such as drug screening, regenerative medicine, and tumor research. One approach that shows promise for studying cancer cell tissue shape, immunological activation, and signaling cascades is the spheroid culture system. Tumor spheroids can decrease the unwanted side effects of medications that are still in development and offer detailed information about various illnesses.

By type, the organoids segment is expected to grow at the fastest rate during the forecast period. The ability to see stem cell morphogens, maintenance, and differentiation that mimic basic tissues in remarkable detail has been made feasible by the creation of human 3D organoid systems, which increases the possibility of studying human physiology and developmental stages. Patient-derived organoids are being utilized for gene repair, transplantation treatment, and customized and regenerative medicine, and they show significant potential for biomedical research and preclinical drug testing.

Application Insights

Application Insights in Organoids and Spheroids Market

By application, the developmental biology segment held the largest share of the organoids and spheroids market in 2023. The field of developmental biology may benefit greatly from the use of organoids. The invention of organoids changed the field of developmental biology and made it possible to examine and alter human development and illness in a lab environment. Organoids are useful for studying the formation and function of various organs, as well as their developmental history. This can be used to assess the efficacy of novel therapies for congenital malformations as well as aid researchers in understanding the underlying causes of these diseases.

By application, the regenerative medicine segment is anticipated to grow at the fastest rate during the forecast period. Organogenesis and the transplantation of organoids are two advanced uses of organoids in regenerative medicine, namely in tissue engineering and stem cell treatment. There is great potential for the field of regenerative medicine to advance with the use of 3D organoids in stem cell treatment. Organoids provide a useful platform for studying the development of organs, modeling illness, and evaluating the efficacy of stem cell-based treatments. Researchers can examine the properties and interconnections of stem cell regeneration in the proper physiological setting by utilizing 3D organoids. This facilitates the development of innovative approaches and a better understanding of the mechanisms underlying tissue regeneration. In terms of modeling illnesses and bridging the gap between pre-clinical research and clinical application, the use of organoids offers the ability to solve several research hurdles.

Regional Insights

By region, North America dominated the organoids and spheroids market in 2023. The American healthcare system, which is frequently ranked among the best in the world, provides quick access to a highly specialized network of doctors who are at the forefront of creating and using innovative, state-of-the-art treatments and drugs. The United States spends $3.8 trillion on healthcare in total. Every major city usually has a large number of highly competent doctors available to patients, giving them the freedom to select the facility, doctor, and level of expertise that best suits them. The American healthcare system has made large investments in pharmaceutical and medical research, which have produced ground-breaking findings and enhanced therapies across a range of specialties. The U.S. and Canada are the two main nations that support the expansion of the organoids and spheroids market in the area.

The U.S. is ideally positioned to lead the world in the rapidly developing field of customized medicine. Additionally, new regulations are being implemented in the U.S. to improve access to healthcare services and insurance. The patient group that has to be treated by clinicians is becoming more and more diversified as health insurance becomes more widely available. The U.S. has adopted telehealth as a novel strategy to address this need. From 0.3 million in 2010 to 27.6 million in 2022, more Americans will be using telehealth. Since the United States has made significant investments in research, it has become a leader in medical innovation, producing cutting-edge medications and medical technologies.

Additionally, there is a greater need for spheroids research due to the rising number of cancer cases in the United States; spheroids are typically employed to investigate malignant cells. The U.S. demographic investigations estimate that there will be 10 million cancer-related deaths and 20 million new instances of the disease each year.

Cancer Cases in the U.S. in 2023 - 2040

Recent Developments

  • In May 2024, the world's first internet platform for remote biological neuron experimentation has been made available by FinalSpark, a trailblazing Swiss biocomputing business. Dedicated to creating the world's first living processor, the platform offers round-the-clock access to sixteen human brain organoids. Because they are made of living neurons with the ability to learn and process information, these bioprocessors have the potential to reduce the environmental effect of the growing usage of computers because they require a million times less power than typical digital processors.
  • In May 2024, Parallel Bio, a biotech firm that uses the immune system to treat disease, announced the launch of its Clinical Trial in a Dish, a tool for early-stage drug development that uses human models to evaluate the safety and effectiveness of novel immunotherapies. Twenty medication candidates are being tested by five pharmaceutical firms, one of which is a Fortune 500 company, as an alternative to animal testing. Using immunological organoids scaled with robotics, Clinical Trial in a Dish builds human models that reflect the biology and variety of a community.

Segments Covered in Organoids and Spheroids Market Report

By Type

  • Organoids
    • By Type
      • Neural Organoids
      • Hepatic Organoids
      • Intestinal Organoids
      • Other Organoids
    • By Method
      • General Submerged Method for Organoid Culture
      • Crypt Organoid Culture Techniques
      • Air Liquid Interface (ALI) Method for Organoid Culture
      • Clonal Organoids from Lgr5+ Cells
      • Brain and Retina Organoid Formation Protocol
      • Others
    • By Source
      • Primary Tissues
      • Stem Cells
  • Spheroids
    • By Type
      • Multicellular Tumor Spheroids (MCTS)
      • Neurospheres
      • Mammospheres
      • Hepatospheres
      • Embryoid Bodies

By Method

  • Micropatterned Plates
  • Low Cell Attachment Plates
  • Hanging Drop Method
  • Others

By Source

  • Cell Line
  • Primary Cell
  • iPSCs Derived Cells

By Application

  • Developmental Biology
  • Personalized Medicine
  • Regenerative Medicine
  • Disease Pathology Studies
  • Drug Toxicity & Efficacy Testing

By Region

  • North America
    • U.S.
    • Canada
  • Europe
    • UK
    • Germany
    • France
    • Italy
    • Spain
    • Sweden
    • Norway
    • Denmark
  • Asia Pacific
    • China
    • Japan
    • India
    • Australia
    • Thailand
    • South Korea
  • Latin America
    • Brazil
    • Mexico
    • Argentina
  • Middle East and Africa
    • Saudi Arabia
    • South Africa
    • UAE
    • Kuwait

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About The Author

Deepa has certified the degree of Master’s in Pharmacy in the Pharmaceutical Quality Assurance department from Dr D.Y. Patil College of Pharmacy. Her research is focused on the healthcare industry. She is the author or co-author of four Review Articles, which include Solid dispersion a strategic method for poorly soluble drugs and solubility improvement techniques for poorly soluble drugs, Herbal Drugs Used In Treatment Of Cataracts, Nano sponges And Their Application in Cancer Prevention and Ayurvedic Remedies of Peptic ulcer. She has also published a Research Article on the Formulation and Evaluation of Mucoadhesive Tablets of Miconazole cocrystal which was published in GIS Science Journal Volume 9 Issue 8. Her passion for secondary research and desire to take on the challenge of solving unresolved issues is making her flourish is the in the research sector.

FAQ's

Embryoid bodies, tumor spheroids, hepatospheres, mammospheres and neurospheres.

Liver organoids, tumor organoids, thyroid organoids, retinal organoids, gastrointestinal organoids, midbrain and multilineages organoids.

Spheroids are round, spherical cells that are often cultivated as free-floating aggregates and may not be very complicated in terms of how they resemble tumor architecture. Broadly speaking, organoids are defined as cells cultured in three dimensions to create structural units that have some resemblance to an organ in terms of both function and structure.

World Health Organization, National Institutes of Health, National Library of Medicine, National Cancer Institute and National Science Foundation.