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Liver Cancer Drugs Market Size Envisioned at USD 9.94 Billion by 2032

Liver Cancer Drugs Market Size Envisioned at USD 9.94 Billion by 2032

The report covers Liver Cancer Drugs Market Size and Companies such as Bayer AG, Bristol-Myers Squibb Company, Eisai Co., Ltd., Exelixis, Inc., Merck KGaA, Pfizer Inc., Eisai Inc., Eli Lilly and Company and F. Hoffmann-La Roche Ltd. offering a range of therapies. The market is segmented by drug class, including chemotherapy, targeted therapy, immunotherapy and others. Distribution channels include hospitals, clinics, retail pharmacies and online pharmacies. The report offers the value (in USD Billion) for the above segments.

Liver Cancer Drugs Market Size and Recent Developments

The liver cancer drugs market size was valued at USD 2.67 billion in 2023 and is projected to reach USD 9.94 billion by 2032, registering a CAGR of 14.2% from 2024 to 2032.

Liver Cancer Drugs Market Size 2023 - 2032

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Report Highlights:

  • Targeted therapies contributed to the largest market share of 52% in 2022.
  • Hospital pharmacies accounted for a commanding 71% market share in 2022.
  • North America led the market with the largest 34% market share in 2022.

With over 800,000 fatalities per year, liver cancer ranks as the fourth most common cause of death worldwide.

Public health authorities are extremely concerned about liver cancer because clinical cases are rising annually and the disease has a 30%–35% projected 5-year survival rate after diagnosis. The formation of malignant cells in the tissues of the liver is primary liver cancer. When cancer forms in other parts of the body and then is transferred to the liver is not primary liver cancer, instead, it can be considered metastatic cancer. Hepatocellular carcinoma is the most common form of liver cancer (approximately 90%) among others. Hepatoblastoma and intrahepatic carcinoma are some other types of liver cancers that are not very common. The cause of liver cancer is unknown but at times, chronic hepatitis infections can ultimately lead to liver cancer. Rising hepatitis B and hepatitis C can lead to an increased risk of developing liver cancer.

For instance,

  • According to the WHO estimates for 2019, there were 296 million individuals worldwide who had a chronic hepatitis B infection, with 1.5 million new cases occurring each year. 

Hepatitis B caused around 820000 deaths across the globe mostly due to hepatocellular carcinoma and liver cirrhosis (primary liver cancer). First-line treatment for advanced liver cancer involves a variety of medications and immunotherapy, while second-line treatment consists of chemotherapeutic medications derived from both natural and synthetic sources. First-line treatments include sorafenib and lenvatinib; second-line treatments include regorafenib and ramucirumab. The best course of treatment for liver cancer varies mostly on the stage at which the disease is progressing. Tyrosine kinase inhibitors (TKIs), among other second-line treatments, have been demonstrated in a large population of patients with uHCC, including those who have had immunotherapy, to prolong survival and improve outcomes while maintaining a stable safety profile. Surgical options include hepatectomy and liver transplantation, as well as ablation and radiation therapy.

CSIR’s Updates on Liver Cancer Research January 2024

Central Drug Research Institute, India conducted a collaborative study indicating that preventing this difficult disease may include focusing on the metabolic alterations that occur in cells.

  • The study, which was conducted in conjunction with CIMAP, CBMR, and CSIR-CDRI, concentrated on hepatocellular carcinoma (HCC), the most prevalent kind of liver cancer.
  • According to the study, cancer cells experience a change in their metabolic programming, which may be used for prophylactic and diagnostic purposes.
  • Under the direction of CSIR-CDRI's Dr. Madhav Nilakanth Mugale, the study used an animal model to simulate how human HCC develops.
  • The investigation noted distinct modifications linked to the advancement of HCC, such as reduced body mass, increased serum enzyme levels, and modifications to the hepatic architecture.
  • This study, which was published in the esteemed international magazine Elsevier, provides opportunities for the development of metabolic reprogramming-based targeted medicines.

Liver Cancer Risks and Diabetes

Excess fat is produced in people with type 2 diabetes because their liver is unable to continuously regulate excessive blood sugar levels. Liver cancer is more likely to occur in those with nonalcoholic fatty liver disease.

Nonalcoholic Fatty Liver Disease (NAFLD) can cause irreversible hepatic inflammation and scarring, leading to cirrhosis. Liver damage and an increased risk of liver cancer are caused by type 2 diabetes, which initiates a series of complex health concerns. The risk of liver cancer is two to four times higher in those with type 2 diabetes than in people without diabetes.

Based on the February 2024 update, a readily measurable biophysical characteristic can be used to identify Type 2 diabetics who don't satisfy the existing screening standards but are at elevated risk of liver cancer, according to a Stanford Medicine study.

Study Implications:

  • According to current standards, people with cirrhosis should be the primary candidates for liver cancer screening.
  • Many high-risk people are left out of this method, especially those with Type 2 diabetes who might not develop cirrhosis.
  • The latest research indicates that screening procedures should be reevaluated to include patients with diabetes, as this could result in earlier detection and better outcomes.
  • Beyond liver cancer, the research may have an impact on screening plans for other diabetes-related malignancies, such as breast cancer.

Recent Therapy Advances

Over the past few years, several big players in cancer therapeutics have come into the picture for studying and developing new treatment approaches for liver cancers. Manufacturers are actively performing clinical trials on the combination therapies and developing advanced treatment options.

For instance,

  • In March 2024, a Japan-based company Terumo launched B-TACE (Balloon-TACE) an advanced therapy for the management of liver cancer. Terumo's B-TACE device, Occlusafe, allows patients to receive chemotherapy drugs to the tumor with more precision and targeting. Furthermore, there is less harm done to the surrounding healthy tissues.
  • In February 2024, Biosyngen’s BST02 received a Fast Track Designation (FTD) grant from the US FDA that covers the management of all forms of liver cancer, such as cholangiocarcinoma and hepatocellular carcinoma.
  • In January 2024, AstraZeneca’s EMERALD-1 Phase III trial yielded positive results, indicating that patients with hepatocellular carcinoma (HCC) who were eligible for embolization saw a statistically significant and clinically meaningful improvement in the primary endpoint of progression-free survival (PFS) when Imfinzi (durvalumab) was combined with TACE and bevacizumab instead of TACE alone.
  • In November 2023, a Japan-based company Terumo launched B-TACE (Balloon-TACE) an advanced therapy for the management of liver cancer. Terumo's B-TACE device, Occlusafe, allows patients to receive chemotherapy drugs to the tumor with more precision and targeting. Furthermore, there is less harm done to the surrounding healthy tissues.

Targeted Therapy for Hepatocellular Carcinoma

With 90% of all instances ever reported, Hepatocellular Carcinoma (HCC) is the most common basic liver cancer. With a mere 3% 5-year survival rate, HCC ranks third in terms of cancer-related deaths. Patients have experienced clinical improvements in the advanced stages because of systemic therapy, but the prognosis is still quite bad. Novel molecular-targeted medicines have been created and clinically tested in the last few decades, with intriguing outcomes. Still, there is a pressing need for research into new medicines given the poor prognoses and limited advantages from current systemic therapy. Here comes the role of targeted and advanced therapies.

Worldwide Percent of New Cancer Cases in 2022

The prognosis is still quite miserable, but systemic therapy is the only ones that show any clinical effect in the latter stages. Therefore, to enhance the clinical results of patients with advanced HCC, new systemic treatment options must be developed. Novel molecular-targeted treatments have been created in the past few decades. More specifically, several small compounds that target Receptor Tyrosine Kinases (RTKs) have been tested in clinical settings.

Sr. No. Type of Therapy Targeted Therapies
1. Tyrosine Kinase Inhibitors Sorafenib
2. VEGF Inhibitors Bevacizumab + Atezolizumab
3. Other Targeted Agents Donafenib
Galunisertib + Sorafenib

Over the past 16 years, the treatment landscape of hepatocellular carcinoma has exhibited a significant transformation due to major advancements in targeted therapy. This growing journey can be attributed to several factors such as:

  • Sorafenib (2007): Sorafenib being the first ever effective and approved targeted therapy for advanced HCC, marked a turning point in liver cancer therapeutics. This innovation opened new doors to more therapeutic developments.
  • Emerging Treatment Options: New targeted medicines such as Lenvatinib and the combination of Bevacizumab and Atezolizumab have become viable first-line therapeutic choices for patients with advanced HCC, capitalizing on the therapeutic efficacy of Sorafenib. The introduction of Ramucirumab, Regorafenib, and Cabozantinib (for patients with AFP > 400 ng/mL) has greatly expanded the therapeutic choices available for advanced HCC patients receiving second-line treatment.

Patients with advanced HCC can now expect better treatment outcomes and a more optimistic prognosis because of these developments in targeted therapy.

BST02’s Fast Track Designation Grant, a Recent Clinical Advancement

BST02 is Biosyngen’s ( an immune-oncology company) immune therapy product that received the FDA’s Fast Track Development Grant in February 2024 for its clinical development to treat all types of liver cancer. BST02's developer, Biosyngen, is pushing the boundaries of cancer treatment development and approval by using the patient's immune system to fight cancer—a strategy that may even surpass more established TIL medicines. Adoptive immune cell treatment technique includes BST02, a T cell therapy that is based on the patient's own tumor infiltrating lymphocytes growing larger. It has the potential to treat liver cancer in all its forms, giving sufferers fresh hope. Compared to conventional TIL therapies, BST02 has many advantages, such as the capacity to get over geographic restrictions because of its cryopreserved form and the decreased requirement for large interleukin-2 dosages.

Geographical Differences of Liver Cancer

The incidence and prevalence of non-infectious diseases have sharply grown in recent decades, despite significant progress in their prevention and control.

Liver cancer ranks second in terms of cancer-related deaths and is the sixth most frequent type of cancer in Asia. Approximately 609,596 new cases of liver cancer were reported in Asia in 2020, making up roughly 72.5% of the global liver cancer incidence.

There are regional differences as well; sub-Saharan Africa and East Asia have the greatest rates, although their underlying reasons are distinct. High-income nations have seen a decrease in liver cancer cases as a result of widespread viral hepatitis treatment and vaccination programs. On the other hand, there is a rise in low-income nations, which is frequently related to dangerous injection techniques and viral hepatitis.

Liver Cancer Drugs Market Players

  • Bayer AG
  • Bristol-Myers Squibb Company
  • Eisai Co., Ltd.
  • Exelixis, Inc.
  • Merck KGaA
  • Pfizer Inc.
  • Eisai Inc.
  • Eli Lilly and Company
  • F. Hoffmann-La Roche Ltd.

Liver Cancer Drugs Market Segments

By Drug Class

  • Targeted Therapy 
    • Bevacizumab
    • Cabozantinib
    • Lenvatinib
    • Ramucirumab
    • Regorafenib
    • Sorafenib
    • Other Targeted Therapies
  • Immunotherapy 
    • Atezolizumab with Bevacizumab
    • Nivolumab with Ipilimumab
    • Pembrolizumab
    • Durvalumab with Tremelimumab
    • Other Immunotherapies
  • Chemotherapy 
    • Gemcitabine
    • Oxaliplatin
    • Cisplatin
    • Doxorubicin
    • 5-fluorouracil
    • Capecitabine
    • Mitoxantrone
    • Other Chemotherapies

By Distribution Channel

  • Hospital Pharmacy
  • Retail Pharmacy
  • Online Pharmacy

By Geography

  • North America
  • Europe
  • Asia Pacific
  • Middle East and Africa
  • South America

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About The Author

Namrata Bukshet is not just a market researcher; she is a detective, a storyteller, and a champion for healthier lives. Her journey began with a Bachelor of Pharmacy degree and a thirst for knowledge that led her to pursue a Post Graduate Diploma in Pharmaceutical Management. Her curiosity for consumer behaviour and market trends burned bright. She delved deep into the world of lifestyle disorders, conducting extensive research that sheds light on the intricate dance between personal choices and societal pressures. This exploration culminated in a groundbreaking paper on E-Biz: Indias 1st G2B Online Portal, presented at an international conference, where her insights resonated with a global audience. But Namrata has impact extends far beyond a single paper. Her expertise has shaped the very landscape of market research and pharmaceuticals. Her keen eye for detail and unwavering commitment to understanding the why behind consumer behaviour have made her a sought-after professional in the industry. She is the decoder ring that unlocks the secrets hidden within data, the translator who turns complex trends into actionable insights. As she continues to unravel the mysteries of consumer behaviour, she paves the way for a future where healthcare is not just about treatment but about understanding the why and building a bridge to a healthier world, one insightful discovery at a time.


In the upcoming years, the liver cancer drugs market is anticipated to rise significantly due to factors like increased research and development, an expanding patient base, and an emphasis on personalized therapy.

Some major obstacles to the approval of new drugs are as follows: Safety-related issues: Carefully assessing the possible adverse effects of novel medications is necessary. Authorities that oversee cost-effectiveness consider the potential advantages of a treatment about its cost.

Despite recent progress, liver cancer treatment still needs a great deal of improvement. These unfulfilled needs include: improved medications for advanced hepatic carcinoma decreased adverse effects and increased efficacy, early identification, and diagnosis.

Global Cancer Observatory, American Liver Foundation, World Health Organization, National Institute of Health.