Towards Healthcare
Protein Labeling Market Size | 8.48% CAGR by 2033

Protein Labeling Market Size to Hit USD 5.55 Bn by 2033

The report covers Protein Labeling Market Trends and Segments Analysis by product, method, application and region. By product includes reagents (proteins, enzymes, probes/tags, monoclonal antibodies and other reagents), kits and services. Methods are divided into in-vitro labeling methods (such as enzymatic labeling, dye-based labeling, co-translational labeling, site-specific labeling, nanoparticle labeling and others) and in-vivo labeling methods (including photoreactive and radioactive labeling, among others). Applications encompass immunological techniques, cell-based arrays, fluorescence microscopy, protein microarray and mass spectrometry. The report offers the value (in USD Billion) for the above segments.

Protein Labeling Market Size, Manufacturers and Stats Analysis Report

The global protein labeling market size was estimated at US$ 2.46 billion in 2023 and is projected to grow US$ 5.55 billion by 2033, rising at a compound annual growth rate (CAGR) of 8.48% from 2024 to 2033. Protein labeling is used in research and diagnosis of various diseases, which drives the growth of the market.

Protein Labeling Market Revenue 2023 - 2033

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Key Takeaways

  • North America led the market with the largest revenue share of 42% in 2023.
  • By product, the reagents segment has held the major revenue share of 64% in 2023.
  • By method, the in- vitro segment has contributed more than 71% of revenue share in 2023.
  • By application, the immunological techniques segment accounted for the largest revenue share of 41% in 2023.
  • By application, the fluorescence microscopy segment is anticipated to grow at the solid CAGR of 9.78% during the forecast period.

Industry at a Glance

The protein labeling market includes methods for protein modification, such as the addition of fluorophores, biotin, and other tiny molecules to study protein-protein interactions and protein folding to look into the general structure and biological function of proteins. It is a very helpful procedure in a lot of areas, such as genetics, forensics, biology, biotechnology and medicine. An essential method in chemical biology is the chemical tagging of proteins using artificial low-molecular-weight probes. Researchers may look into a variety of features and the overall biological activity of proteins thanks to the availability of site-specific alterations. Measuring biological processes, accurately quantifying compounds, identifying specific protein modifications and isoforms in multiplexed samples, improving detection sensitivity, and streamlining detection workflows are the main goals of the protein labeling market.

Top Companies in the Protein Labeling Market

  • Thermo Fisher Scientific, Inc.
  • LI-COR, Inc.
  • Shiru
  • F. Hoffmann-La Roche Ltd
  • Jena Bioscience GmbH
  • Merck KGaA
  • New England Biolabs.
  • Promega Corporation.
  • Revvity Inc.
  • LGC Ltd
  • Agilent Technologies Inc.
  • Danaher (Cytiva)
  • EvolutionaryScale

EvolutionayScale's Recent Launch in the Protein Labeling Market

Company Name EvolutionaryScale
Headquarters New York, U.S.
Pipeline In June 2024, EvolutionaryScale, founded by former academics from Meta's AI research lab, said that it had secured $142 million in first funding, led by Lux Capital and with participation from AWS and NVIDIA's venture capital division. The company EvolutionaryScale has also just introduced the ESM3 AI model, which allows scientists and researchers to create protein-design processes, incorporate antibody expertise, and create complex, novel multi-domain proteins from scratch.

Agilent Technologies Inc. Recent Launch in the Protein Labeling Market

Company Name Agilent Technologies Inc.
Headquarters California, U.S.
Pipeline In January 2024, the Agilent ProteoAnalyzer system is a new automated parallel capillary electrophoresis system for protein analysis that Agilent Technologies Inc. unveiled during the 23rd Annual PepTalk Conference, held in San Diego from January 16–19. This new platform facilitates the investigation of complex protein mixtures, an essential stage in analytical workflows in the food analysis, biotech, pharmaceutical, and academic sectors. It also makes the process easier and more efficient.

Growing Biological Research Drives the Protein Labeling Market

Biological research frequently uses protein labeling for a number of reasons. Using microscopy methods, fluorescent labels may be used to visualize the position of proteins within cells or tissues. This can aid researchers in the study of protein kinetics and localization. Quantifying the quantity of a particular protein in a sample may be done with labels. This is especially helpful for methods like enzyme-linked immunosorbent assay (ELISA) and Western blotting. Through the use of methods like co-immunoprecipitation and pull-down experiments, labels may be utilized to investigate the relationships between proteins. Researchers can examine protein function in real-time by using labels to track the mobility or activity of proteins in living cells or organisms.

Protein Instability During Tag Removal is a Restraint to the Protein Labeling Market’s Growth

The target protein may become unstable again if solubilizing fusion tags are removed for use in downstream processes like target protein crystallization. In the event that tag removal is necessary, co-expression in conjunction with a chaperone or antibody fragment binding would be a better course of action. Chaperones help freshly generated proteins fold correctly while hiding the hydrophobic portions of the target protein to stop protein aggregation. As a result, problematic proteins are frequently co-expressed with chaperones such as trigger factor (TF), GroES/L, or protein disulfide isomerase (PDI).

Targeted Protein Degradation is an Emerging Technology in the Protein Labeling Market

In order to find new drug targets and possible treatments, experts in the fields of illness research and drug development are closely examining targeted protein degradation technologies. Bifunctional molecules that are intended to attach to a target disease protein on one end and to bind to an E3 ligase on the other end in order to remove the protein from the cell are used in proteolysis-targeting chimeras technology. These compounds are a potent protein labeling technique for illness research because of their broad range of disease target specificity and capacity to target particular disease targets for protein breakdown using internal cellular protein degradation mechanisms.

Report Highlights

Product Insights

By product, the reagents segment held the largest protein labeling market share in 2023. Target proteins can be specifically labeled using a variety of chemicals. Classic dyes, fluorescent labels, tests, biotinylation reagents, radioisotope labels, molecular probes, and labeling kits are among the products offered. Protein labeling chemicals can be used to label not just proteins but also other molecules such as ligands, peptides, antibodies, and synthetic oligonucleotides. They are available for use in a number of applications, including probes of biological structure, function, and relationships, immunochemistry, fluorescence in situ hybridization (FISH), and receptor labeling.

For instance,

  • In May 2024, a research study was published that showcases a novel molecular probe that is capable of getting selectively activated in response to labile Cu+. This molecular probe will be used for protein labeling in a cellular environment which will be Cu+ rich. In the study, it was found that the probe had excellent Cu+ selectivity.

Method Insights

By method, the in-vivo segment is expected to grow at the fastest rate during the forecast period. When labeled nucleotides or amino acids are cultivated in a cell, it is possible to label every nucleic acid or protein in the cell using a technique known as "in-vivo labeling." Through DNA replication, translation, and protein turnover, all DNA, RNA, and proteins are tagged over extended cell growth in a medium containing labeled nucleic acids or amino acids. Prior to doing more research, the target protein or nucleic acid can be purified. Labeling every species of protein or nucleic acid uniformly is one advantage of in-vivo labeling.

The commercial availability of a wide range of tools and reagents for in-vivo protein labeling has made these techniques more accessible to researchers. This includes fluorescent and bioluminescent tags, transgenic animal models, and advanced imaging systems. The availability of these resources supports the widespread adoption of in-vivo labeling methods. In-vivo protein labeling allows for non-invasive imaging and repeated measurements in the same living organism. This reduces the need for large numbers of animals in experiments, aligning with ethical considerations and regulations regarding the use of animals in research. The reduction in animal usage is a significant advantage, promoting the adoption of in-vivo techniques.

Application Insights

By application, the immunological techniques segment dominated the protein labeling market in 2023. In immunology, bioconjugation of proteins in live cells is a potent technology that makes it easy to produce protein reagents and allows for the imaging of protein production, trafficking, and function. The immune system may be engineered by the use of protein and other macromolecule labeling. To enhance retention duration and influence the immune response, for instance, the expression of a protein antigen fused to an expression partner may be helpful. Visualizing the function of proteins in cellular processes is made possible by bioconjugation in living cells, which offers several options in immunological applications. Labeling proteins to track the effects of their interactions on signaling pathways and to examine how they interact with one another is one of the most popular uses. It is also frequently advantageous for vaccination applications to label the antigen in order to track its trafficking in tissues, cells and organisms.

By application, the fluorescence microscopy segment is anticipated to grow at the fastest rate during the forecast period. Biological specimens are labeled with a wide variety of chemical dyes, and fluorescent labeling is crucial to biological research. Fluorescent labeling is renowned for being highly sensitive and non-destructive. As a result, it is now one of the most used techniques for tracking and marking biomolecules. Depending on the type of target, many fluorescent labeling techniques can be applied. Target protein fluorescence labeling in living cells makes it possible to see the distribution, interactions, and dynamics of the protein within the cell.

For instance,

  • In August 2023, researchers developed a fluorescent microscope with organized illumination for rapid super-resolution imaging across a wide field of view. This new type of microscope can look at several live cells at once with extremely high resolution, which is useful for investigating the effects of different drugs and drug combinations on the body.

Regional Insights

By region, North America dominated the protein labeling market in 2023. An advanced and well-organized healthcare system exists in both the United States and Canada, two countries in North America. These systems promote research and development. The increasing range of applications for protein labeling is contributing to the growth of this field of study. Policies in these nations support this kind of study as well. Global participants are encouraged to enter the U.S. and Canada by these policies. These nations benefit from the existence of several global market participants. Additionally, it is anticipated that the region's revenue development will be aided by the growing use of genetic sequencing and customized medicine throughout the course of the projection year. The development of high-throughput proteomics platforms, improvements in mass spectrometry, and the integration of proteomics with other omics technologies, such as genomics and metabolomics, are projected to propel the growth of the protein labeling market in the U.S. during the forecast period.

Recent Developments in Protein Labeling Market

  • In May 2024, Shiru, the Protein Discovery Company, will unveil the first-ever marketplace and platform for protein discovery. Anybody may search for, test, and buy molecules on for application in food, agriculture, personal hygiene, and inventive material uses. Scholars, big incumbents, and startups can now leverage the power of enormous libraries of natural protein sequences, proprietary, trained AI models, and automated biochemistry workflows through an easy-to-use online interface thanks to Shiru's marketplace and discovery approach, which was first for the industry. Around 33 million chemicals are included in the searchable database, which is arranged according to factors including effective expression, functional application, and sequencing.
  • In March 2024, researchers at Boston College developed a unique and low-cost method for precisely altering proteins using a little electrical charge. This technique has the potential for the development of innovative biotherapeutics and protein-based research instruments. Under the guidance of Chemistry Professors Abhishek Chatterjee and Eranthie Weerapana, the group created and refined a unique electrochemical protein labeling reaction known as "eCLIC," which permits accurate alteration of 5-hydroxytryptophan (5HTP) residues that are site-specifically integrated into a variety of proteins, including therapeutic antibodies that are full length.

Segments Covered in Protein Labeling Market Report

By Product

  • Reagents
    • Proteins
    • Enzymes
    • Probes/Tags
    • Monoclonal Antibodies
    • Other Reagents
  • Kits
  • Services

By Method

  • In-vitro Labeling Methods
    • Enzymatic Labeling
    • Dye-based Labeling
    • Co-translational Labeling
    • Site-specific Labeling
    • Nanoparticle Labeling
    • Others
  • In-vivo Labeling Methods
    • Photoreactive Labeling
    • Radioactive Labeling
    • Others

By Application

  • Immunological Techniques
  • Cell-based Arrays
  • Fluorescence Microscopy
  • Protein Microarray
  • Mass Spectrometry

By Region

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Denmark
    • Sweden
    • Norway
  • Asia Pacific
    • China
    • Japan
    • India
    • South Korea
    • Australia
    • Thailand
  • Latin America
    • Brazil
    • Argentina
  • MEA
    • South Africa
    • Saudi Arabia
    • UAE
    • Kuwait

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About The Author

Deepa has certified the degree of Master’s in Pharmacy in the Pharmaceutical Quality Assurance department from Dr D.Y. Patil College of Pharmacy. Her research is focused on the healthcare industry. She is the author or co-author of four Review Articles, which include Solid dispersion a strategic method for poorly soluble drugs and solubility improvement techniques for poorly soluble drugs, Herbal Drugs Used In Treatment Of Cataracts, Nano sponges And Their Application in Cancer Prevention and Ayurvedic Remedies of Peptic ulcer. She has also published a Research Article on the Formulation and Evaluation of Mucoadhesive Tablets of Miconazole cocrystal which was published in GIS Science Journal Volume 9 Issue 8. Her passion for secondary research and desire to take on the challenge of solving unresolved issues is making her flourish is the in the research sector.


Mass tags, fluorophores and stable isotopes are the common methods of protein labeling.

Bromomethylketones, iodoacetamides, benzylic halides and maleimides.

Mass spectrometry is a high-throughput tool used for studying proteins.

National Institutes of Health, NCBI, Thermo Fisher Scientific, BioPharma Dive and Genetic Engineering & Biotechnology News