Towards Healthcare
Cell Separation Market 9.98% - CAGR Growth by 2033

Cell Separation Market Size (USD 23.56 Bn) by 2033

The report covers Cell Separation Market Segmentations by Products such as Consumables (reagents, kits, media, sera, beads and disposables) and Instruments (centrifuges, flow cytometers, filtration systems and magnetic-activated cell separator systems). Cell Types addresses human and animal cells. Techniques analyzes Centrifugation, Surface Marker and Filtration. The Applications explores biomolecule isolation, cancer research, stem cell research, tissue regeneration, in vitro diagnostics and therapeutics. The report offers the value (in USD Billion) for the above segments.

Cell Separation Market Size and Competitive Landscape Report

The global cell separation market size was estimated at US$ 9.10 billion in 2023 and is projected to grow US$ 23.56 billion by 2033, rising at a compound annual growth rate (CAGR) of 9.98% from 2024 to 2033. The rising prevalence of infectious and chronic diseases drives the market’s growth.

Cell Separation Market Revenue 2023 - 2033

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Key Takeaways

  • North America dominated the cell separation market with the largest revenue share of 41% in 2023.
  • Asia Pacific is expected to grow at a fastest CAGR of 15.65% during the forecast period.
  • By product, the consumables segment has contributed more than 63% of revenue share in 2023.
  • By cell type, the animal cells segment has generated the biggest revenue share of 55% in 2023.
  • By cell type, the human cells segment is projected to grow at a solid CAGR of 12.50% during the predicted period.
  • By technique, the centrifugation segment has held a major revenue share of 43% in 2023.
  • By technique, the surface marker technique is estimated to grow at a notable 12.40% CAGR during 2024-2033.
  • By application, the biomolecule isolation segment has captured more than 31% of revenue share in 2023.
  • By application, the cancer research segment is registering a solid CAGR of 10.16% during the projected period.

Industry at a Glance

The cell separation market is growing significantly due to the application of cell separation in various fields, including therapeutic protein production, biologics, diagnostics, oncology research, and so on. Cell separation is the process of separating one or more particular cell populations from a heterogeneous mixture of cells. It is also sometimes referred to as cell isolation or sorting. By reducing the influence of other cell types in the sample, conducting tests on isolated cells enables scientists to securely respond to certain research topics. There are several uses for isolated cells in life science research. One of the main drivers of the need for customized medications and the development of efficient generalized techniques for treating big populations is cell separation.

Top Companies in the Cell Separation Market

  • Akadeum Life Sciences
  • Corning Inc.
  • Merck KGaA
  • STEMCELL Technologies Inc.
  • Bio-Rad Laboratories, Inc.
  • Terumo Corp.
  • BD
  • Agilent Technologies, Inc.
  • Danaher
  • Thermo Fisher Scientific, Inc.
  • LevitasBio

Recent Launch by Akadeum in the Cell Separation Market

Company Name Akadeum Life Sciences
Headquarters Michigan, U.S.
Recent Launch In May 2024, in Baltimore, Maryland, for the 27th Annual Meeting of the American Society of Gene & Cell Therapy, Akadeum Life Sciences, the leading company in buoyancy-based cell separation, is launching several cutting-edge new technologies. With a wide selection of GMP-grade solutions as a consequence of their unmatched product development speed, Akadeum has demonstrated its dedication to revolutionizing clinical cell therapy research and development for millions of patients globally.

Recent Launch by LevitasBio in the Cell Separation Market

Company Name LevitasBio
Headquarters California, U.S.
Recent Launch In November 2023, in order to create and produce its revolutionary new LeviCell® EOS system for cell separation and enrichment during sample preparation, LevitasBio® has teamed up with Planet Innovation. Several units of the LeviCell EOS have already been placed at prestigious research facilities around the United States since its mid-year introduction, which saw robust early sales. Researchers may get higher-quality samples for further study with the LeviCell EOS system because it employs the same ground-breaking Levitation Technology as its predecessor, LeviCell 1.0, to enhance cell populations without changing, straining, or harming cells.

Rising Chronic Diseases is Driving Cell Separation Market

Global Deaths Due to Chronic Diseases Each Year (In Millions)

Some of the leading causes of morbidity and death globally have been and still are chronic illnesses, including diabetes, heart disease, stroke and cancer. By 2030, chronic illness is predicted to cost the global economy $47 trillion. Chronic illness is a huge financial burden on the American healthcare system, costing the country about $1 trillion annually. Noncommunicable diseases (NCDs) account for 41 million annual deaths worldwide, or 74% of all fatalities, according to the WHO. 17 million individuals die from NCDs before they become 70 years old every year; low- and middle-income nations account for 86% of these premature fatalities.

Cell separation is useful in chronic conditions for isolating specific cell populations for analysis and treatment. By separating diseased cells from healthy cells, researchers can study the specific characteristics of the diseased cells and develop targeted treatments. This process also allows for the isolation of rare cells for further study, potentially leading to a better understanding of the disease mechanisms and more effective therapeutic interventions.

High Cost of Equipment & Cell-based Research Restraints the Cell Separation Market

Cell biology is studied in-depth to develop cutting-edge therapeutics like gene and stem cell therapies. To obtain accurate findings, the best reagents, instruments, and other supplies must be utilized in this study. The reason that cell biology research is expensive is that it has to maintain strict guidelines and follow rules issued by regulatory agencies. Furthermore, the majority of cell treatment trials have a low success rate and virtually little research involving cells has proven fruitful. Many organizations and small enterprises are unable to afford to buy pricey items because of budgetary constraints. One of the primary factors impeding the growth of the cell separation instrument market is this.

Rising Demand for Cell Therapies is Creating Opportunities for the Cell Separation Market

A valuable technique employed in many areas of biological and biomedical research, as well as therapeutic medicine, is cell separation. The quality of repair and the ensuing clinical result of cell-based therapeutic therapies may be enhanced by the application of highly selective cell separation techniques. A growing number of researchers are employing or wishing to utilize cell separation methods as a consequence of this potential, which has led to an increase in the use of these approaches in the disciplines of tissue engineering and regenerative medicine.

For instance,

  • In April 2024, OrganaBio announced the release of HematoPACTM-HSC-CB-GMP, on-demand CD34+ hematopoietic stem cells (HSCs) that are ethically produced from fresh human cord blood and comply with current good manufacturing practice (cGMP) regulations. The novel product uses OrganaBio's expertise in GMP manufacturing and cell separation to generate exceptionally high yields of highly viable CD34+ HSC cells quickly, which may be utilized in the creation of next-generation cell treatments.

New Cancer Cases and Deaths Worldwide (In Millions)

Report Highlights

Product Insights

The consumables segment dominated the cell separation market by 63% in 2023. Consumables include kits and reagents, media, beads and disposables, which are used for cell growth and further preparation for isolation. As little as eight minutes might be required to extract highly pure cells using some of the quickest cell isolation kits. A number of commercial instruments, kits, and reagents are available for density gradient centrifugation separation. Cell growth media, cell labeling chemicals, and cell separation solutions are all included in the kits and reagents. Cell isolation, which is also known as cell separation or sorting, is a technique that uses magnetic beads to target cells for depletion or selection using ligands or antibodies that are specific to certain cell surface antigens. Methods for magnetic bead cell separation allow for both positive and negative cell selection in addition to cell depletion.

For instance,

  • In May 2024, the MARS® IngenuityTM Reagent kits for quick and simple cell separation were just released, according to Applied Cells. Both RUO and GMP-grade reagents are available in this cutting-edge product range, which has been specially designed to work with our own MARS® Bar platform. This innovative combination provides an all-in-one solution for the separation of high-quality immunomagnetic cells, assisting in the advancement of cell therapy.

Cell Type Insights

By cell type, the animal cells segment held the dominant share of the cell separation market by 55% in 2023. The process of isolating cells and cultivating them in artificial environments is usually used in animal cell culture. Animal cell culture is an essential approach in the development of viral vaccines. Hematopoietic growth factors, growth factors, hormones, blood products, and enzymes are among the recombinant therapeutic proteins that may be produced in animal cell cultures. Innovations in gene therapy depend on the advancement of animal cell culture. Large-scale manufacturing of proteins and antibodies—which would otherwise need a significant financial outlay—can be achieved through the use of animal cells.

By cell type, the human cells segment is anticipated to show the fastest growth during the predicted period. In order to do biomedical research, human cell culture is now required. Even though cell culture has been shown to have an impact on gene expression, human cell culture techniques are necessary to examine the impact of human genetic diversity on gene expression. The ability of human cell-based research to provide mechanistic and therapeutic insights has been greatly enhanced by technological advancements. Human cell culture finds its greatest value in the stem cell business, where mesenchymal stem cells may be grown and cryopreserved for later use. For hundreds of thousands of patients each year, tissue engineering may provide significantly better, more affordable healthcare.

For instance,

  • In September 2023, the introduction of their 'Human T Cell Activation & Expansion Kit' with microbubbles for buoyancy-activated cell sorting (BACS) was announced by Akadeum Life Sciences, the world leader in buoyancy-based cell separation technology. T cell expansion, activation, and isolation from a sample are all accomplished with this unique kit in a single, easy procedure.

Technique Insights

By technique, the centrifugation segment held the largest cell separation market share in 2023. With the use of gradient media, density gradient centrifugation divides cell populations according to their relative densities. Differential centrifugation is an additional method of centrifugation that divides particles according to size. Bypassing the sample through the centrifuge several times without a density gradient enables particles with the same density to be distinguished by distinct characteristics. Depending on the centrifuge's size, centrifugation may be helpful for separating materials on a big scale. Consistency in efforts might lead to a higher total yield.

For instance,

  • In January 2024, a new centrifuge control system called X Control was unveiled by GEA with the goal of "elevating integration, connectivity, data processing, and security to a new level." Artificial intelligence (AI) integration is made possible by the new X Control. This attempts to facilitate data collecting and analysis, as well as system-wide self-optimization. Moreover, better interaction with Supervisory Control and Data Acquisition (SCADA) systems would result from the enhanced processing capability.

By technique, the surface marker technique is estimated to grow at the fastest CAGR during 2024-2033. With FACS, the most highly pure cellular preparations are produced by utilizing a fluorescently tagged antibody as the cell-surface marker. A range of surface markers can be combined to distinguish between distinct cell subsets. Cell markers have the ability to facilitate the cell's key functions beyond simple categorization. In addition to being employed as therapy targets, these cell markers can aid in diagnosis. Cell types may be distinguished, and scientists can target certain cell subsets by using cell surface markers that are only expressed in that group of cells.

For instance,

  • In August 2023, the world leader in clinical diagnostic products and life science research, Bio-Rad Laboratories, Inc., today announced the release of StarBright Red 670, the 29th StarBright dye, and the addition of 29 more highly validated antibodies conjugated to StarBright Blue 700 and StarBright Violet 610 Dyes to its current range. The extended range increases research opportunities in veterinary immunology by providing more diversity and adaptability in conventional and full-spectrum multicolor flow cytometry panels. Together with extra mouse and human targets, it also has dog, cow and pig targets.

Application Insights

The biomolecule isolation segment dominated the cell separation market in 2023 by application. Biomolecules are molecules produced by living organisms. They can be nucleic acids, carbohydrates, metabolites, proteins, hormones, and lipids. Different living organisms and cells produce different types of biomolecules. Cell separation techniques make the production and isolation of biomolecules easy and efficient. Through the use of cell separation methods, it is possible to isolate certain cells that may then be cultivated to create biomolecules on a large scale. Biomolecules may be generated and synthesized on a large scale utilizing sophisticated procedures, and they can be modified to make them appropriate for the suggested uses. Biomolecules are used in a wide range of sectors, including wastewater treatment, biofuels, textiles, pharmaceuticals, cosmetics and pulp and paper.

By application, the cancer research segment is estimated to grow significantly during the projected period. For many years, it has been evident how important early cancer detection and better cancer treatment are. This has led to an international investigation into new avenues for the use of technical advancements in cancer patient care. Since circulating tumor cells (CTC) may have a significant role in early cancer diagnosis and prognosis, one of the main areas of research is the isolation and detection of CTC.

Additionally, the market for cell separation is expanding due to the frequency of cancer. A major cause of death throughout the globe is cancer. As people age, their chance of developing certain cancers increases, which is most certainly the cause of the sharp increase in cancer incidence. The following are risk factors for non-communicable illnesses like cancer: air pollution, alcoholism, bad food, physical inactivity and tobacco use.

Regional Insights

Cell Separation Market NA, APAC, EU, LA, MEA Share

North America dominated the cell separation market in 2023. Many things contribute to its importance, one of which is the existence of well-established biotechnology and pharmaceutical businesses, especially in the United States. The region's market position is further strengthened by the high pace at which technologically innovative solutions are adopted. Moreover, there is a considerable need for cell separation solutions due to the broad research projects undertaken by research universities in North America, especially in the area of cell treatments.

In the U.S., the prevalence of chronic disorders and other health issues increased the demand for research and development and personalized medicines that use cell separation for the study of biomolecules and the development of vaccines, antibodies, and cell therapies. These factors contribute to the growth of the cell separation market in the U.S.

For instance,

  • In the U.S., there will be an estimated 2,001,140 new instances of cancer identified in 2024 and 611,720 deaths from the illness. 15,590 children and teenagers between the ages of 0 and 19 are predicted to lose their lives to cancer in 2024, out of an expected 14,910 new cases of the illness.

According to the U.S. Department of Health and Human Services, an estimated 129 million Americans suffer from at least one severe chronic illness (1), such as diabetes, cancer, heart disease, obesity, or hypertension. Four in ten Americans suffer from two or more chronic diseases, and twelve percent have five or more. Treatment and management of chronic illnesses and mental health issues account for around 90% of the $4.1 trillion in healthcare spending that occurs each year.

Asia Pacific is anticipated to grow at the fastest rate during the forecast period. The pharmaceutical and biotechnology sectors in developing nations like China and India are seeing significant growth, which is the reason for this expansion. Increased healthcare spending and the growing market penetration of large international companies in important Asia-Pacific nations are other factors driving the growth of the cell separation market. The need for cell separation solutions in the area has also been boosted by continuing stem cell and gene therapy research projects in nations like South Korea, China and Japan.

China's venture capital investment market for breakthrough medicine has seen a significant change in recent years. China is a leader in the field of cell treatment, especially when it comes to CAR-T therapy or chimeric antigen receptor T-cell therapy. The extraordinary rise of cell therapy in China has also been greatly aided by the nation's NMPA. To show how committed the government is to these goods, the NMPA produced eight rules in 2022 alone to hasten the clinical development of cell therapy drugs.

For instance,

  • In May 2024, researchers in China announced a possible cell therapy treatment for type 2 diabetes, a positive discovery for millions of people suffering from the disease. The research, published in the journal Cell Discovery, describes a 59-year-old man with type 2 diabetes who received effective therapy. The process entailed growing islet cells, which are responsible for making insulin, in the lab and transplanting them into the patient.

Recent Developments in the Cell Separation Market

  • In July 2024, a leading provider of microfluidic cell sorting technology, NanoCellect Biomedical, is pleased to announce the release of VERLOTM Image-Guided Cell Sorter, a revolutionary device that is set to revolutionize gentle flow cytometry analysis, single-cell imaging, and cell sorting.
  • In November 2023, a novel technique was developed by the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) Interdisciplinary Research Group (IRG) that allows the direct extraction of mesenchymal stem cells (MSCs) from pure bone marrow, also referred to as bone marrow aspirate (BMA), which is a crucial source of MSCs, without the need for dilution. By employing a novel continuous sorting process on a multi-chip Deterministic Lateral Displacement (DLD) microfluidic device, the new procedure reduces the time required to extract MSCs from bone marrow samples to around 20 minutes and doubles the amount of MSCs obtained.

Segments Covered in the Report

By Product

  • Consumables
    • Reagents, Kits, Media and Sera
    • Beads
    • Disposables
  • Instruments
    • Centrifuges
    • Flow Cytometers
    • Filtration Systems
    • Magnetic-activated Cell Separator Systems

By Cell Type

  • Human Cells
  • Animal Cells

By Technique

  • Centrifugation
  • Surface Marker
  • Filtration

By Application

  • Biomolecule Isolation
  • Cancer Research
  • Stem Cell Research
  • Tissue Regeneration
  • In Vitro Diagnostics
  • Therapeutics

By Region

  • North America
    • U.S.
    • Canada
  • Europe
    • UK
    • Germany
    • France
    • Italy
    • Spain
    • Russia
    • Denmark
    • Sweden
    • Norway
  • Asia Pacific
    • Japan
    • China
    • India
    • South Korea
    • Australia
    • Singapore
    • Thailand
  • Latin America
    • Brazil
    • Mexico
    • Argentina
  • Middle East & Africa
    • South Africa
    • Saudi Arabia
    • UAE
    • Kuwait

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About The Author

Deepa has certified the degree of Master’s in Pharmacy in the Pharmaceutical Quality Assurance department from Dr D.Y. Patil College of Pharmacy. Her research is focused on the healthcare industry. She is the author or co-author of four Review Articles, which include Solid dispersion a strategic method for poorly soluble drugs and solubility improvement techniques for poorly soluble drugs, Herbal Drugs Used In Treatment Of Cataracts, Nano sponges And Their Application in Cancer Prevention and Ayurvedic Remedies of Peptic ulcer. She has also published a Research Article on the Formulation and Evaluation of Mucoadhesive Tablets of Miconazole cocrystal which was published in GIS Science Journal Volume 9 Issue 8. Her passion for secondary research and desire to take on the challenge of solving unresolved issues is making her flourish is the in the research sector.

FAQ's

Cells are different and produce different biomolecules. In order to study different cells, the production of a single type of cell on a large scale and the use of specific cells for the production of vaccines, antibodies or any other bio-based products, cell separation is needed.

Cells get separated based on cell size, density, surface proteins and immunodensity.

National Cancer Institute and Centers for Disease Control and Prevention