Towards Healthcare
Diabetic Ketoacidosis Treatment Market to Lead USD 971.46 Mn by 2035

Diabetic Ketoacidosis Treatment Market Driven by Advanced Rapid Insulin Progress

According to market projections, the diabetic ketoacidosis treatment sector is expected to grow from USD 930.89 million in 2025 to USD 1426.15 million by 2035, reflecting a CAGR of 4.36%. The diabetic ketoacidosis treatment market  due to rising investment and collaboration by the major players. North America is leading the market because of the strong presence of major players.

Category: Therapeutic Area Insight Code: 6433 Format: PDF / PPT / Excel

The global diabetic ketoacidosis treatment market size is calculated at US$ 930.89 million in 2025, grew to US$ 971.46 million in 2026, and is projected to reach around US$ 1426.15 million by 2035. The market is expanding at a CAGR of 4.36 % between 2025 and 2034.

Diabetic Ketoacidosis Treatment Market Trends and Growth (2025)

The growing incidence of diabetes, which the International Diabetes Federation estimates affects approximately 589 million individuals worldwide as of 2024 and is expected to reach 853 million by 2050, is one of the main factors driving the diabetic ketoacidosis treatment market. Technological developments in insulin administration and fluid control, together with rising knowledge of DKA symptoms and available treatments, are driving market expansion.

Key Takeaways

  • Diabetic ketoacidosis treatment industry poised to reach USD 930.89 million by 2025.
  • Forecasted to grow to USD 1426.15 million by 2035.
  • Expected to maintain a CAGR of 4.36% from 2026 to 2035.
  • North America dominated the diabetic ketoacidosis treatment market in 2024, with approximately 35-38% share.
  • Asia Pacific is expected to grow at the fastest CAGR during the forecast period.
  • By treatment type, the insulin therapy segment dominated the market in 2024, with approximately 28-40% share.
  • By treatment type, the monitoring & diagnostics segment is expected to grow at the fastest CAGR during the forecast period.
  • By route of administration/product form, the parenteral/IV segment dominated the market in 2024, with approximately 60% share.
  • By route of administration/product form, the oral/enteral segment is expected to grow at the fastest CAGR during the forecast period.
  • By care setting/end-user, the hospitals & emergency departments segment dominated the market in 2024, with approximately 70-80% share.
  • By care setting/end-user, the ambulatory/homecare segment is expected to grow at the fastest CAGR during the forecast period.
  • By patient group/age, the adults segment dominated the diabetic ketoacidosis treatment market in 2024.
  • By patient group/age, the pediatrics segment is expected to grow at the fastest CAGR during the forecast period.

Quick Facts Table

Table Scope
Market Size in 2025 USD 930.89 Million
Projected Market Size in 2035 USD 1426.15 Million
CAGR (2026 - 2035) 4.36%
Leading Region North America
Market Segmentation By Treatment Type, By Route of Administration/Product Form, By Care Setting/End User, By Patient Group/Age, By Region
Top Key Players Novo Nordisk A/S, Eli Lilly and Company, Sanofi, Biocon/Biocon Biologics, Baxter International Inc., Fresenius Kabi, B. Braun Melsungen AG, Pfizer Inc., Merck & Co., Inc., Abbott Laboratories, Roche Diagnostics, Siemens Healthineers, Beckman Coulter (Danaher), Dexcom, Inc., Medtronic plc, Insulet Corporation, Smiths Medical (Becton, Dickinson & Co./BD), EKF Diagnostics/Nova Biomedical, Ascensia Diabetes Care/Arkray

What is Diabetic Ketoacidosis Treatment?

Diabetic ketoacidosis (DKA) is an acute, potentially life-threatening complication of diabetes (most commonly type 1) characterized by hyperglycaemia, ketonaemia/ketonuria, and metabolic acidosis. The diabetic ketoacidosis treatment market covers pharmaceuticals, intravenous fluids & electrolytes, devices (point-of-care glucose/ketone/blood-gas analyzers), infusion systems, and hospital/critical-care services used to diagnose, stabilize, and manage DKA episodes. Standard care (fluid resuscitation, insulin therapy, electrolyte repletion, and supportive/critical care) drives the majority of market demand; growing complements include point-of-care ketone testing, integration of continuous glucose monitoring (CGM), and protocolized care pathways.

Diabetic Ketoacidosis Treatment Market Outlook

  • Industry Growth Overview: The rising incidence of diabetes worldwide, an increase in DKA ER admissions, and notable technical developments in insulin treatments and diagnostics are the main causes of this growth.  Advanced continuous glucose monitoring (CGM) and ultra-rapid insulins are examples of innovations that are enhancing early identification and treatment.
  • Global Expansion: The market is widely distributed, with North America holding a dominant market share because of its highly developed healthcare system and high rate of diabetes. Due to government initiatives, improved healthcare access, and rising diabetes incidence, the Asia-Pacific and Middle East/Africa regions are experiencing the fastest market growth. Strategic alliances, home care environments, and telemedicine are all part of the expansion initiatives.
  • Major Investors: Large, international pharmaceutical and medical device companies are the main participants and investors in the diabetic ketoacidosis treatment market. These companies, which dominate the insulin market and make significant investments in research and development for novel formulations and delivery methods, include Novo Nordisk, Eli Lilly and Company, and Sanofi. Abbott Laboratories, Pfizer, Medtronic, and Baxter International are other noteworthy organizations that are actively investing in cutting-edge DKA management solutions.
  • Protocolized, audit-driven DKA care pathways standardize the use of fluids/insulin and reduce complications.
  • Rising use of CGM and telehealth for prevention and early detection of ketosis/euglycemic DKA.
  • Hospitals remain core purchasers, but home-use ketone testing and integrated monitoring are fastest fastest-growing submarkets.
  • Product innovation focuses on safer insulin-infusion protocols (reduced hypokalaemia risk), balanced crystalloids vs normal saline debate, and rapid point-of-care ketone quantification.

How is AI useful in the Diabetic Ketoacidosis Treatment Market?

By evaluating enormous volumes of patient data and offering preventive analytics, AI has demonstrated its critical role in early interventions and preventive care. AI is revolutionizing real-time monitoring with CGMs, insulin pumps, and other gadgets. AI's significance in customizing treatment regimens for diabetic ketoacidosis is being bolstered by ongoing advancements in automated insulin delivery systems. The crucial use of AI in the treatment of diabetic ketoacidosis is being further propelled by the growing need for personalized medicine.

Segmental Insights

Treatment Type Insights

Why Insulin Therapy Dominated the Market in 2024?

The insulin therapy segment dominated the diabetic ketoacidosis treatment market in 2024, with a share of approximately 28-40%. The American Diabetes Association suggests regular insulin by continuous IV infusion as the preferred treatment for all but mild cases of DKA. Insulin therapy is one component of managing DKA. If implemented, the safe practice of early basal insulin use may result in better patient-centered outcomes that are advantageous to health systems.

Monitoring & Diagnostics

The monitoring & diagnostics segment is expected to grow at the fastest CAGR during the forecast period. For DKA to be treated safely and effectively, ongoing monitoring and diagnostics are essential. They enable medical professionals to verify the diagnosis, evaluate the severity, direct treatment in real time, spot and treat potentially fatal complications, and ascertain when DKA has subsided.

Fluid Replacement Therapy

The fluid replacement therapy segment is estimated to grow at a significant rate in the diabetic ketoacidosis treatment market during 2025-2034. An important part of the acute management of diabetic ketoacidosis (DKA) is the administration of intravenous fluid to increase intravascular, interstitial, and intracellular volume in addition to insulin therapy. The most widely used fluid for this purpose is saline (0.9% sodium chloride, also known as normal saline), which is also the main fluid that is advised in the most recent DKA clinical practice guidelines.

Route of Administration/Product Form Insights

Why was the Parenteral/IV Segment Dominant in the Market in 2024?

The parenteral/IV segment dominated the diabetic ketoacidosis treatment market in 2024, with approximately 60% share. For patients with DKA, intravenous infusion is the recommended method of insulin administration. The best course of treatment is intravenous insulin and fluids if the patient is unable to tolerate oral intake. It is an initial and optimal choice of administration due to its quick onset of action, effective delivery of large volumes of fluids and medications, and precise control over medication levels.

Oral/Enteral

The oral/enteral segment is expected to grow at the fastest CAGR during the forecast period. In order to encourage a quicker recovery and shorter hospital stays, it is administered as soon as the patient is stable and conscious. By encouraging quicker metabolic stabilization and hospital discharge, the oral/enteral route plays a critical and beneficial role in the recovery phase of DKA.

Care Setting/End-User Insights

Which Care Setting/End-User Dominated the Market in 2024?

The hospitals & emergency departments segment dominated the diabetic ketoacidosis treatment market in 2024, with approximately 70-80% share. Diagnosing and treating diabetic ketoacidosis (DKA) is primarily done in emergency departments (EDs). In many hospitals, they are usually treated in an intensive care unit (ICU).

Ambulatory/Homecare

The ambulatory/homecare segment is expected to grow at the fastest CAGR during the forecast period. For mild-to-moderate diabetic ketoacidosis (DKA), ambulatory or home care treatment has several benefits, such as decreased medical expenses, fewer hospital stays, and enhanced patient empowerment and quality of life. For carefully chosen patients, it is a secure and efficient substitute for admission to the intensive care unit (ICU).

Diagnostic/Point-Of-Care Clinics

The diagnostic/point-of-care clinics segment is estimated to grow at a significant rate in the diabetic ketoacidosis treatment market during 2025-2034. When treating diabetic ketoacidosis (DKA), point-of-care (POC) testing has several benefits. Its quick results allow for prompt clinical decision-making, which may shorten hospital stays and increase patient involvement.

Patient Group/Age Insights

How the Adults Segment Dominated the Market in 2024?

The adults segment dominated the diabetic ketoacidosis treatment market in 2024. The number of DKA and HHS admissions has increased over the past ten years, according to international reports. Recent data indicates a 55% increase in the rate of DKA hospitalizations, particularly among adults under 45. Younger adults with type 1 diabetes are more likely to have DKA, while older adults with type 2 diabetes are more likely to have HHS.

Pediatrics

The pediatrics segment is expected to grow at the fastest CAGR during the forecast period. One of the most frequent and feared side effects of diabetes is diabetic ketoacidosis (DKA), particularly in children with type 1 diabetes (T1DM). Nearly 41% of all pediatric T1DM patients present with DKA, according to a cohort study conducted in the USA, which reports a 2% increase in incidence. Hospitalization rates for DKA have been rising over the last ten years, indicating the disease's growing burden.

Which Region Dominated the Market in 2024?

North America dominated the diabetic ketoacidosis treatment market in 2024. The number of patients with type 1 and type 2 diabetes has significantly increased in North America. Continuous improvements in delivery systems, new insulin analogs, and treatment techniques to improve glycemic control and shorten recovery times are introducing quick, creative solutions to the market. The quick decentralization of healthcare also contributes to market innovations.

What are the Trends in the U.S. Market?

As the eighth most common cause of death in the U.S., diabetes is one of the most dangerous health issues our nation has ever encountered. Over 38 million adults suffer from diabetes, and 98 million have prediabetes. Diabetes is the most costly chronic condition, with medical expenses and lost wages, and work totaling $413 billion annually. The costs of care for those who have the disease are double those of those who do not.

Rising Diabetes Cases a Major Concern in the Asia Pacific

Asia Pacific is estimated to host the fastest-growing diabetic ketoacidosis treatment market during the forecast period. The market is expected to benefit from the rising prevalence of type 1 diabetes and the growing popularity of sedentary lifestyles. Other important elements that are likely to support the growth include the large number of elderly people and the growing use of successful tactics by top Chinese and Indian businesses.

India’s Bold ‘75 by 25’ Drive Powers Growth in Diabetic Ketoacidosis Treatment Market

75 million people with diabetes will receive better care by 2025 thanks to the 2024 partnership between WDF, WHO, and India's Health Ministry under the "75 by 25" roadmap. The initiative lowers the risk of diabetic ketoacidosis by enhancing early detection, glucose monitoring, and medication accessibility. The expanding diabetic ketoacidosis treatment market in India is supported by improved access to treatment through strengthened primary care and digital monitoring.

Key Players Making the Market Grow in Europe

Europe is expected to grow at a significant CAGR in the diabetic ketoacidosis treatment market during the forecast period led by nations like France, Germany, and the United Kingdom, because of their proactive diabetes management and robust healthcare systems. Businesses like Novo Nordisk and Sanofi, which propel advancements in insulin therapy, benefit the region. By authorizing innovations like Medtronic's insulin pumps, the European Medicines Agency (EMA) guarantees the safety of treatment.

Government Funding Promotes the Market’s Growth in the UK

Instead of implementing a single, new "investment" program for 2024–2025, the UK government is funding diabetes through targeted initiatives, general health research funding, and ongoing NHS service funding. It is estimated that complications from diabetes cost the UK healthcare system £6.2 billion a year.

South America's Emergency Room Evolution

South America is expected to grow significantly in the diabetic ketoacidosis treatment market during the forecast period. Across South America, the market is seeing significant expansion in hospital infrastructure investment, with a focus on emergency care protocols. Undiagnosed diabetes remains a critical issue, forcing reliance on late-stage DKA intervention. Biosimilar insulin adoption is lowering costs and improving patient access to lifesaving therapy.

The Brazilian Diabetes Tsunami: Fueling Acute Care

The Diabetic Ketoacidosis treatment market in Brazil is surging, propelled by a staggering diabetes prevalence of 10.6% in adults as of 2024. This growth drives significant demand for essential intravenous fluids and fast-acting insulin analogs in emergency departments. Local manufacturing partnerships are enhancing product availability.

Middle East's High-Tech DKA Defense

The Middle East and Africa are expected to grow at a lucrative CAGR in the diabetic ketoacidosis treatment market during the forecast period. The broader Middle East and Africa region is witnessing robust market growth due to rising diabetes rates, where approximately 85 million adults have diabetes. Increased government spending and the adoption of continuous glucose monitoring devices and advanced insulin pumps by advanced medical centers are standardizing DKA care.

UAE's Premium Push for Precision Treatment

The UAE is an epicenter of DKA market growth, driven by a high adult diabetes prevalence of 20.7%. The focus here is on precision medicine, quickly adopting next-generation ultra-rapid insulins and advanced diagnostic tools for swift and accurate treatment, setting a regional gold standard.

Diabetic Ketoacidosis Treatment Market Value Chain Analysis

R&D

R&D for DKA treatments entails finding and evaluating new treatments in lab and animal studies, such as automated delivery systems or faster-acting insulins. The objective is to find novel, safe substances that more effectively treat acidosis, hyperglycemia, and dehydration in order to submit an Investigational New Drug (IND) application for human testing.

Clinical Trials and Regulatory Approvals

Clinical trials (Phases I-III) in humans assess safety, efficacy, and optimal dosing compared to existing standard care. A New Drug Application (NDA), which is submitted to regulatory agencies such as the FDA for marketing approval, is based on the positive outcomes of these extensive trials. Long-term effects are tracked through post-marketing (Phase IV) surveillance.

Patient Support and Services

Sustained assistance is essential for preventing and recovering from DKA. Comprehensive patient education on "sick day rules," self-care, and home ketone monitoring is among the services offered. To prevent recurrence, an interprofessional team comprising endocrinologists, nurses, and social workers offers education on medication adherence, lifestyle modifications, and guarantees access to essential medical supplies.

Company Landscape

Novo Nordisk A/S

Company Overview:

Novo Nordisk is a global healthcare company with over 100 years of innovation in diabetes care. The company is a world leader in the diabetes and obesity segments, with a strong portfolio of insulins, GLP-1 receptor agonists, and related delivery devices.

Corporate Information (Headquarters, Year Founded, Ownership Type):

  • Headquarters: Bagsværd, Denmark
  • Year Founded: 1923 (through the merger of Nordisk Insulinlaboratorium and Novo Terapeutisk Laboratorium)
  • Ownership Type: Publicly traded company (NYSE: NVO, OMX: NOVO B), majority of voting shares held by the Novo Nordisk Foundation

History and Background:

  • Pioneered insulin production in Scandinavia in the 1920s.
  • Focused solely on diabetes care and other serious chronic diseases since its inception.
  • Has a long history of developing new and improved insulins, including monocomponent insulin and human insulin.

Key Milestones/Timeline:

  • 1923: Founding of Novo Terapeutisk Laboratorium.
  • 1985: Launch of the NovoPen, a revolutionary insulin delivery system.
  • 2000s: Introduction of modern insulin analogs (e.g., NovoLog/NovoRapid).
  • 2025 (Jan): Received FDA approval for an innovative ultra-rapid insulin analog designed to reduce DKA recovery time by up to 30% (latest reported news).

Business Overview:

  • Focused on discovering, developing, manufacturing, and marketing pharmaceutical products.
  • Core focus is on diabetes and obesity, with an increasing presence in rare blood and endocrine disorders.
  • Ambitious goal to be present and competitive in all diabetes segments and to increase its diabetes market share to more than 1/3 by 2025 (based on 2019 strategy).

Business Segments/Divisions:

  • Diabetes and Obesity Care (Largest segment, includes insulin, GLP-1, and related delivery systems)
  • Rare Disease (Includes treatments for hemophilia and growth disorders)

Geographic Presence:

  • Commercial presence in over 80 countries.
  • Production facilities globally, with major sites in Denmark, the USA, Brazil, China, and France.

Key Offerings:

  • Insulin for DKA Treatment: Rapid-acting insulins like NovoLog (Insulin Aspart) and Fiasp (Insulin Aspart injection) for acute DKA management and IV infusion.
  • Insulin Delivery Systems: Smart pens with dose memory (e.g., NovoPen 6, NovoPen Echo Plus).

End-Use Industries Served:

  • Hospitals (Dominant end-user for acute DKA treatment and IV insulin administration)
  • Ambulatory Surgical Centers (ASCs)
  • Specialty Clinics
  • Homecare Settings (for long-term diabetes management and prevention of DKA recurrence)

Key Developments and Strategic Initiatives:

Mergers & Acquisitions: Focused on smaller, strategic acquisitions and technology collaborations in areas like digital health and cell therapy.

Partnerships & Collaborations:

May 2025: Collaborating with hospitals in Southeast Asia to train AI models to predict blood glucose and ketone readings, aiming for better DKA risk prediction.

Product Launches/Innovations:

  • 2025 (Jan): FDA approval for a new ultra-rapid insulin analog specifically aimed at accelerating glycemic control in acute hospital settings for DKA.
  • Development of once-weekly basal insulin (Insulin Icodec), expected to simplify long-term diabetes management and reduce DKA risk.
  • Capacity Expansions/Investments: Continuous high investment in global manufacturing capacity, particularly for GLP-1s and advanced insulin.
  • Regulatory Approvals: Continuous stream of approvals for next-generation insulin and delivery devices across major markets (US, EU, China).
  • Distribution channel strategy: Leveraging a vast global network, including direct sales to hospitals and partnerships with major retail and online pharmacies.

Technological Capabilities/R&D Focus:

  • Core Technologies/Patents: Advanced protein and peptide formulation technologies; smart insulin pen technology. Holds numerous patents on its proprietary insulin analogs (e.g., Fiasp, Tresiba).
  • Research & Development Infrastructure: State-of-the-art research centers globally, heavily focused on diabetes, obesity, and other chronic diseases.
  • Innovation Focus Areas: Ultra-rapid and once-weekly insulin analogs, oral protein therapies, stem cell-based treatments, and integrated digital health solutions (AI/CGM/Smart Pens).

Competitive Positioning:

  • Strengths & Differentiators:
    • Global market leader in overall diabetes care (Insulin and GLP-1).
    • Strongest and broadest portfolio of modern insulin analogs and proprietary delivery devices.
    • Significant recent innovation specifically targeting accelerated DKA resolution (ultra-rapid insulin approval in 2025).
    • Market presence & ecosystem role: A dominant force, setting standards for diabetes management protocols worldwide. Its insulin products are fundamental to DKA treatment protocols.

SWOT Analysis:

  • Strengths: Strongest diabetes portfolio; R&D leadership in next-gen insulins; excellent geographic reach.
  • Weaknesses: High dependence on the diabetes and obesity market; ongoing pressure on insulin pricing in key markets.
  • Opportunities: Expansion of ultra-rapid insulin for DKA; integration of AI and digital health into DKA prevention/management; growth in emerging markets.
  • Threats: Biosimilar competition (e.g., biosimilar insulin glargine); competitor innovation in ultra-rapid insulin; regulatory hurdles for novel therapies.

Recent News and Updates:

  • Press Releases:
    • Jan 2025: Announced FDA approval of its new ultra-rapid insulin analog, highlighting its potential to cut DKA recovery time by 30%.
    • Industry Recognitions/Awards: Consistently ranks among the top pharmaceutical innovators, particularly for its advancements in diabetes and GLP-1 therapies

Eli Lilly and Company

Company Overview:

Eli Lilly and Company is one of the world's largest pharmaceutical companies, with a major historical and current focus on diabetes treatment, including the development of the first commercially available insulin. It is a key competitor in the DKA market.

Corporate Information (Headquarters, Year Founded, Ownership Type):

  • Headquarters: Indianapolis, Indiana, USA
  • Year Founded: 1876
  • Ownership Type: Publicly traded company (NYSE: LLY)

History and Background:

  • Revolutionized diabetes care in 1923 by commercializing Insulin, derived from the discovery by Banting and Best.
  • Has been a pioneer in developing subsequent generations of insulin, including human insulin and modern analogs.

Key Milestones/Timeline:

  • 1923: Commercialized the first insulin product.
  • 1996: Launched Humalog (Insulin Lispro), the first rapid-acting insulin analog, which is a staple in DKA treatment.
  • 2022: Launched Lyumjev (Insulin Lispro-aabc), an ultra-rapid-acting insulin.
  • 2025 (Apr): Declared extended clinical trials for a new ultra-rapid insulin for the treatment of acute DKA episodes (latest reported news).

Business Overview:

  • Engaged in the discovery, development, manufacture, and marketing of pharmaceutical products.
  • Key therapeutic areas include Diabetes, Oncology, Immunology, Neuroscience, and others.
  • The Diabetes segment, largely driven by its insulin and GLP-1 portfolio, is a primary revenue generator.

Business Segments/Divisions:

  • Human Pharmaceuticals (Contains the Diabetes business unit, which is highly relevant to DKA treatment)
  • The company does not typically report a separate DKA-specific segment, as DKA treatment is a subset of its comprehensive Diabetes care portfolio.

Geographic Presence:

  • Products are marketed in approximately 70 countries.
  • Research and development facilities and manufacturing plants across various locations globally.

Key Offerings:

  • Insulin for DKA Treatment: Rapid-acting insulins like Humalog (Insulin Lispro) and Lyumjev (ultra-rapid-acting insulin lispro-aabc) are essential for IV infusion during DKA.
  • Other Diabetes Therapeutics: A comprehensive range of GLP-1 receptor agonists (e.g., Trulicity, Mounjaro) and SGLT-2 inhibitors (e.g., Jardiance) for long-term diabetes management and DKA prevention.

End-Use Industries Served:

  • Hospitals (Critical segment, as Humalog/Lyumjev are used extensively for inpatient DKA management)
  • Specialty Clinics and Ambulatory Care Centers
  • Retail and Online Pharmacies (for maintenance therapy)

Key Developments and Strategic Initiatives:

  • Mergers & Acquisitions:

July 2021: Acquired Protomer Technologies Inc. to focus on advancing glucose-responsive insulins, a future DKA prevention/treatment technology.

  • Partnerships & Collaborations:
    • April 2025: Entered a strategic partnership to expand its next-generation ultra-rapid insulin clinical trials specifically for acute DKA management.
    • Oct 2021: Partnered with Cipla (India) to promote, sell, and distribute key diabetic medications like Humalog and Trulicity in India, expanding DKA therapy access in the Asia Pacific.
  • Product Launches/Innovations:
    • 2022: Launched Lyumjev (Insulin Lispro-aabc), a quicker-acting form of lispro, offering a faster treatment option for DKA.
    • August 2020: Introduced cost-effective unbranded insulin products (e.g., unbranded Humalog) to improve access for patients at high risk of DKA.
    • Regulatory Approvals: Continuous global approvals for its modern insulin portfolio (e.g., Humalog, Lyumjev) and new GLP-1/GIP therapies.
  • Technological Capabilities/R&D Focus:
    • Core Technologies/Patents: Holds core patents on multiple insulin analogs (e.g., Lispro, Glargine biosimilars) and multi-agonist therapies (Mounjaro).
    • Research & Development Infrastructure: Extensive R&D focus on next-generation diabetes therapeutics, including ultra-rapid insulins and once-weekly basal insulins.
    • Innovation Focus Areas: Glucose-responsive insulins, encapsulated cell therapies for T1D (through Sigilon partnership), once-weekly basal insulins (Basal Insulin-fc in pipeline, forecast for 2026 launch), and ultra-rapid insulins for acute care.

Competitive Positioning:

  • Strengths & Differentiators:
    • Historical pioneer and long-standing experience in insulin manufacturing and DKA protocols.
    • Strong portfolio featuring both traditional rapid-acting insulin (Humalog) and next-generation ultra-rapid insulin (Lyumjev).
    • Significant pipeline investment in future insulin and T1D therapies.
    • Market presence & ecosystem role: One of the two primary global suppliers of essential rapid-acting insulin for DKA management, playing a critical role in global emergency care.

SWOT Analysis:

  • Strengths: Deep legacy and expertise in diabetes; blockbusters in the GLP-1 space; highly successful rapid-acting insulin (Humalog).
  • Weaknesses: Faces intense competition in the insulin market (biosimilars, pricing pressure); has less market share than Novo Nordisk in the overall diabetes market.
  • Opportunities: Launch of ultra-rapid insulin in new DKA protocols; development of a once-weekly basal insulin; expansion of unbranded/low-cost insulin offerings to combat DKA rates.
  • Threats: Patent expiry on key insulins (e.g., Humalog); competition from other ultra-rapid insulin innovators; potential for SGLT-2 inhibitor-related DKA cases (which Lilly addresses with its DKA portfolio).

Recent News and Updates:

  • Press Releases:
    • April 2025: Publicly announced extended clinical trials for its new ultra-rapid insulin for acute DKA episodes, signaling high commitment to the acute care segment.
    • Industry Recognitions/Awards: Regularly receives recognition for its drug development success, especially in diabetes and obesity (e.g., Mounjaro/Zepbound).

Top Vendors in the Market & Their Offerings

Company Key Offerings Contribution to Diabetic Ketoacidosis (DKA) Treatment Market Strategic Initiatives Global Reach
Sanofi Insulins, Glucose monitoring therapies Expands access to rapid-acting insulins, enhancing emergency DKA management Focuses on R&D for advanced insulin formulations Strong presence across North America, Europe, and Asia
Biocon Biologics Biosimilar insulins, affordable biologics Provides cost-effective insulin biosimilars supporting global DKA care Partners with Viatris to expand biosimilar insulin reach Operations in over 100 countries
Baxter International Inc. IV fluids, renal therapies Supplies life-saving IV solutions for rehydration during DKA Invests in advanced electrolyte therapy products Global distribution network across hospitals
Fresenius Kabi Infusion and nutrition products Enhances DKA stabilization through critical care infusions Expands production capacity for parenteral nutrition Active in 100+ healthcare markets
B. Braun Melsungen AG Infusion pumps, insulin delivery systems Supports precision insulin and fluid therapy in DKA Innovates digital infusion monitoring systems Broad European and Asian footprint

Top Companies in the Diabetic Ketoacidosis Treatment Market

  • Novo Nordisk A/S
  • Eli Lilly and Company
  • Sanofi
  • Biocon/Biocon Biologics
  • Baxter International Inc.
  • Fresenius Kabi
  • B. Braun Melsungen AG
  • Pfizer Inc.
  • Merck & Co., Inc.
  • Abbott Laboratories
  • Roche Diagnostics
  • Siemens Healthineers
  • Beckman Coulter (Danaher)
  • Dexcom, Inc.
  • Medtronic plc
  • Insulet Corporation
  • Smiths Medical (Becton, Dickinson & Co./BD)
  • EKF Diagnostics/Nova Biomedical
  • Ascensia Diabetes Care/Arkray

Read further to see how top players are reshaping the Diabetic Ketoacidosis Treatment Market at: https://www.towardshealthcare.com/companies/diabetic-ketoacidosis-treatment-companies 

Recent Developments in the Diabetic Ketoacidosis Treatment Market

  • In November 2025, Glenmark Pharmaceuticals plans to introduce an 8.4% sodium bicarbonate injection in the U.S. This generic drug addresses the body's elevated acidity levels. This month is when the company anticipates starting distribution. The medication is therapeutically comparable to that made by Abbott Laboratories. This action comes after the drug saw notable yearly sales in the U.S. market.
  • In October 2025, the expansion of its strategic partnership with Civica, Inc. (Civica) to include a new Insulin Glargine medication will benefit patients in the United States by expanding the supply of high-quality, reasonably priced insulins, according to Biocon Biologics Ltd. (BBL), a fully integrated global biosimilars company and subsidiary of Biocon Ltd.

Segments Covered in the Report

By Treatment Type

  • Insulin Therapy (IV infusion/parenteral insulin)
  • Fluid Replacement Therapy
  • Electrolyte Replacement
  • Monitoring & Diagnostics
  • Adjunctive/Supportive Therapies

By Route of Administration/Product Form

  • Parenteral/IV
  • Oral/Enteral

By Care Setting/End User

  • Hospitals & Emergency Departments
  • Ambulatory/Homecare
  • Diagnostic/Point-of-Care Clinics

By Patient Group/Age

  • Adults
  • Pediatrics

By Region

  • North America
    • U.S.
    • Canada
    • Mexico
    • Rest of North America
  • South America
    • Brazil
    • Argentina
    • Rest of South America
  • Europe
    • Western Europe
      • Germany
      • Italy
      • France
      • Netherlands
      • Spain
      • Portugal
      • Belgium
      • Ireland
      • UK
      • Iceland
      • Switzerland
      • Poland
      • Rest of Western Europe
  • Eastern Europe
    • Austria
    • Russia & Belarus
    • Türkiye
    • Albania
    • Rest of Eastern Europe
  • Asia Pacific
    • China
    • Taiwan
    • India
    • Japan
    • Australia and New Zealand
    • ASEAN Countries (Singapore, Malaysia)
    • South Korea
    • Rest of APAC
  • MEA 
    • GCC Countries
    • Saudi Arabia
    • United Arab Emirates (UAE)
    • Qatar
    • Kuwait
    • Oman
    • Bahrain
  • South Africa
  • Egypt 
  • Rest of MEA

Tags

  • Last Updated: 11 November 2025
  • Report Covered: [Revenue + Volume]
  • Historical Year: 2021-2023
  • Base Year: 2024
  • Estimated Years: 2025-2034

Meet the Team

Deepa Pandey is a focused and detail-oriented market research professional with growing expertise in the healthcare sector, delivering high-quality insights across therapeutic areas, diagnostics, biotechnology and healthcare services.

Learn more about Deepa Pandey

Aditi Shivarkar is a seasoned professional with over 14 years of experience in healthcare market research. As a content reviewer, Aditi plays a critical role in ensuring the quality and accuracy of all market insights and data presented by the research team.

Learn more about Aditi Shivarkar

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FAQ's

The diabetic ketoacidosis treatment market stands at USD 971.46 million in 2026 and is expected to reach USD 1426.15 million by 2035, growing at a CAGR of 4.36% from 2026 to 2035.

North America is currently leading the diabetic ketoacidosis treatment market due to a high prevalence of diabetes.

The diabetic ketoacidosis treatment market comprises five segments treatment type, route of administration product form, care setting end-user, patient group age, and region.

Key trends include rising diabetic patients and developing countries, and a rise in clinical trials for developing better treatment options.

Ministry of Health and Family Welfare, Government of India, National Institutes of Health, FDA, WHO, PIB, CDC.