November 2025
The global diabetic ketoacidosis treatment market size is calculated at US$ 930.89 million in 2025, grew to US$ 971.46 million in 2026, and is projected to reach around US$ 1426.15 million by 2035. The market is expanding at a CAGR of 4.36 % between 2025 and 2034.

The growing incidence of diabetes, which the International Diabetes Federation estimates affects approximately 589 million individuals worldwide as of 2024 and is expected to reach 853 million by 2050, is one of the main factors driving the diabetic ketoacidosis treatment market. Technological developments in insulin administration and fluid control, together with rising knowledge of DKA symptoms and available treatments, are driving market expansion.
| Table | Scope |
| Market Size in 2025 | USD 930.89 Million |
| Projected Market Size in 2035 | USD 1426.15 Million |
| CAGR (2026 - 2035) | 4.36% |
| Leading Region | North America |
| Market Segmentation | By Treatment Type, By Route of Administration/Product Form, By Care Setting/End User, By Patient Group/Age, By Region |
| Top Key Players | Novo Nordisk A/S, Eli Lilly and Company, Sanofi, Biocon/Biocon Biologics, Baxter International Inc., Fresenius Kabi, B. Braun Melsungen AG, Pfizer Inc., Merck & Co., Inc., Abbott Laboratories, Roche Diagnostics, Siemens Healthineers, Beckman Coulter (Danaher), Dexcom, Inc., Medtronic plc, Insulet Corporation, Smiths Medical (Becton, Dickinson & Co./BD), EKF Diagnostics/Nova Biomedical, Ascensia Diabetes Care/Arkray |
Diabetic ketoacidosis (DKA) is an acute, potentially life-threatening complication of diabetes (most commonly type 1) characterized by hyperglycaemia, ketonaemia/ketonuria, and metabolic acidosis. The diabetic ketoacidosis treatment market covers pharmaceuticals, intravenous fluids & electrolytes, devices (point-of-care glucose/ketone/blood-gas analyzers), infusion systems, and hospital/critical-care services used to diagnose, stabilize, and manage DKA episodes. Standard care (fluid resuscitation, insulin therapy, electrolyte repletion, and supportive/critical care) drives the majority of market demand; growing complements include point-of-care ketone testing, integration of continuous glucose monitoring (CGM), and protocolized care pathways.
By evaluating enormous volumes of patient data and offering preventive analytics, AI has demonstrated its critical role in early interventions and preventive care. AI is revolutionizing real-time monitoring with CGMs, insulin pumps, and other gadgets. AI's significance in customizing treatment regimens for diabetic ketoacidosis is being bolstered by ongoing advancements in automated insulin delivery systems. The crucial use of AI in the treatment of diabetic ketoacidosis is being further propelled by the growing need for personalized medicine.
Why Insulin Therapy Dominated the Market in 2024?
The insulin therapy segment dominated the diabetic ketoacidosis treatment market in 2024, with a share of approximately 28-40%. The American Diabetes Association suggests regular insulin by continuous IV infusion as the preferred treatment for all but mild cases of DKA. Insulin therapy is one component of managing DKA. If implemented, the safe practice of early basal insulin use may result in better patient-centered outcomes that are advantageous to health systems.
Monitoring & Diagnostics
The monitoring & diagnostics segment is expected to grow at the fastest CAGR during the forecast period. For DKA to be treated safely and effectively, ongoing monitoring and diagnostics are essential. They enable medical professionals to verify the diagnosis, evaluate the severity, direct treatment in real time, spot and treat potentially fatal complications, and ascertain when DKA has subsided.
Fluid Replacement Therapy
The fluid replacement therapy segment is estimated to grow at a significant rate in the diabetic ketoacidosis treatment market during 2025-2034. An important part of the acute management of diabetic ketoacidosis (DKA) is the administration of intravenous fluid to increase intravascular, interstitial, and intracellular volume in addition to insulin therapy. The most widely used fluid for this purpose is saline (0.9% sodium chloride, also known as normal saline), which is also the main fluid that is advised in the most recent DKA clinical practice guidelines.
Why was the Parenteral/IV Segment Dominant in the Market in 2024?
The parenteral/IV segment dominated the diabetic ketoacidosis treatment market in 2024, with approximately 60% share. For patients with DKA, intravenous infusion is the recommended method of insulin administration. The best course of treatment is intravenous insulin and fluids if the patient is unable to tolerate oral intake. It is an initial and optimal choice of administration due to its quick onset of action, effective delivery of large volumes of fluids and medications, and precise control over medication levels.
Oral/Enteral
The oral/enteral segment is expected to grow at the fastest CAGR during the forecast period. In order to encourage a quicker recovery and shorter hospital stays, it is administered as soon as the patient is stable and conscious. By encouraging quicker metabolic stabilization and hospital discharge, the oral/enteral route plays a critical and beneficial role in the recovery phase of DKA.
Which Care Setting/End-User Dominated the Market in 2024?
The hospitals & emergency departments segment dominated the diabetic ketoacidosis treatment market in 2024, with approximately 70-80% share. Diagnosing and treating diabetic ketoacidosis (DKA) is primarily done in emergency departments (EDs). In many hospitals, they are usually treated in an intensive care unit (ICU).
Ambulatory/Homecare
The ambulatory/homecare segment is expected to grow at the fastest CAGR during the forecast period. For mild-to-moderate diabetic ketoacidosis (DKA), ambulatory or home care treatment has several benefits, such as decreased medical expenses, fewer hospital stays, and enhanced patient empowerment and quality of life. For carefully chosen patients, it is a secure and efficient substitute for admission to the intensive care unit (ICU).
Diagnostic/Point-Of-Care Clinics
The diagnostic/point-of-care clinics segment is estimated to grow at a significant rate in the diabetic ketoacidosis treatment market during 2025-2034. When treating diabetic ketoacidosis (DKA), point-of-care (POC) testing has several benefits. Its quick results allow for prompt clinical decision-making, which may shorten hospital stays and increase patient involvement.
How the Adults Segment Dominated the Market in 2024?
The adults segment dominated the diabetic ketoacidosis treatment market in 2024. The number of DKA and HHS admissions has increased over the past ten years, according to international reports. Recent data indicates a 55% increase in the rate of DKA hospitalizations, particularly among adults under 45. Younger adults with type 1 diabetes are more likely to have DKA, while older adults with type 2 diabetes are more likely to have HHS.
Pediatrics
The pediatrics segment is expected to grow at the fastest CAGR during the forecast period. One of the most frequent and feared side effects of diabetes is diabetic ketoacidosis (DKA), particularly in children with type 1 diabetes (T1DM). Nearly 41% of all pediatric T1DM patients present with DKA, according to a cohort study conducted in the USA, which reports a 2% increase in incidence. Hospitalization rates for DKA have been rising over the last ten years, indicating the disease's growing burden.
North America dominated the diabetic ketoacidosis treatment market in 2024. The number of patients with type 1 and type 2 diabetes has significantly increased in North America. Continuous improvements in delivery systems, new insulin analogs, and treatment techniques to improve glycemic control and shorten recovery times are introducing quick, creative solutions to the market. The quick decentralization of healthcare also contributes to market innovations.
As the eighth most common cause of death in the U.S., diabetes is one of the most dangerous health issues our nation has ever encountered. Over 38 million adults suffer from diabetes, and 98 million have prediabetes. Diabetes is the most costly chronic condition, with medical expenses and lost wages, and work totaling $413 billion annually. The costs of care for those who have the disease are double those of those who do not.
Asia Pacific is estimated to host the fastest-growing diabetic ketoacidosis treatment market during the forecast period. The market is expected to benefit from the rising prevalence of type 1 diabetes and the growing popularity of sedentary lifestyles. Other important elements that are likely to support the growth include the large number of elderly people and the growing use of successful tactics by top Chinese and Indian businesses.
75 million people with diabetes will receive better care by 2025 thanks to the 2024 partnership between WDF, WHO, and India's Health Ministry under the "75 by 25" roadmap. The initiative lowers the risk of diabetic ketoacidosis by enhancing early detection, glucose monitoring, and medication accessibility. The expanding diabetic ketoacidosis treatment market in India is supported by improved access to treatment through strengthened primary care and digital monitoring.
Europe is expected to grow at a significant CAGR in the diabetic ketoacidosis treatment market during the forecast period led by nations like France, Germany, and the United Kingdom, because of their proactive diabetes management and robust healthcare systems. Businesses like Novo Nordisk and Sanofi, which propel advancements in insulin therapy, benefit the region. By authorizing innovations like Medtronic's insulin pumps, the European Medicines Agency (EMA) guarantees the safety of treatment.
Instead of implementing a single, new "investment" program for 2024–2025, the UK government is funding diabetes through targeted initiatives, general health research funding, and ongoing NHS service funding. It is estimated that complications from diabetes cost the UK healthcare system £6.2 billion a year.
South America is expected to grow significantly in the diabetic ketoacidosis treatment market during the forecast period. Across South America, the market is seeing significant expansion in hospital infrastructure investment, with a focus on emergency care protocols. Undiagnosed diabetes remains a critical issue, forcing reliance on late-stage DKA intervention. Biosimilar insulin adoption is lowering costs and improving patient access to lifesaving therapy.
The Diabetic Ketoacidosis treatment market in Brazil is surging, propelled by a staggering diabetes prevalence of 10.6% in adults as of 2024. This growth drives significant demand for essential intravenous fluids and fast-acting insulin analogs in emergency departments. Local manufacturing partnerships are enhancing product availability.
The Middle East and Africa are expected to grow at a lucrative CAGR in the diabetic ketoacidosis treatment market during the forecast period. The broader Middle East and Africa region is witnessing robust market growth due to rising diabetes rates, where approximately 85 million adults have diabetes. Increased government spending and the adoption of continuous glucose monitoring devices and advanced insulin pumps by advanced medical centers are standardizing DKA care.
The UAE is an epicenter of DKA market growth, driven by a high adult diabetes prevalence of 20.7%. The focus here is on precision medicine, quickly adopting next-generation ultra-rapid insulins and advanced diagnostic tools for swift and accurate treatment, setting a regional gold standard.
R&D for DKA treatments entails finding and evaluating new treatments in lab and animal studies, such as automated delivery systems or faster-acting insulins. The objective is to find novel, safe substances that more effectively treat acidosis, hyperglycemia, and dehydration in order to submit an Investigational New Drug (IND) application for human testing.
Clinical trials (Phases I-III) in humans assess safety, efficacy, and optimal dosing compared to existing standard care. A New Drug Application (NDA), which is submitted to regulatory agencies such as the FDA for marketing approval, is based on the positive outcomes of these extensive trials. Long-term effects are tracked through post-marketing (Phase IV) surveillance.
Sustained assistance is essential for preventing and recovering from DKA. Comprehensive patient education on "sick day rules," self-care, and home ketone monitoring is among the services offered. To prevent recurrence, an interprofessional team comprising endocrinologists, nurses, and social workers offers education on medication adherence, lifestyle modifications, and guarantees access to essential medical supplies.
Company Overview:
Novo Nordisk is a global healthcare company with over 100 years of innovation in diabetes care. The company is a world leader in the diabetes and obesity segments, with a strong portfolio of insulins, GLP-1 receptor agonists, and related delivery devices.
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Mergers & Acquisitions: Focused on smaller, strategic acquisitions and technology collaborations in areas like digital health and cell therapy.
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May 2025: Collaborating with hospitals in Southeast Asia to train AI models to predict blood glucose and ketone readings, aiming for better DKA risk prediction.
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Eli Lilly and Company is one of the world's largest pharmaceutical companies, with a major historical and current focus on diabetes treatment, including the development of the first commercially available insulin. It is a key competitor in the DKA market.
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July 2021: Acquired Protomer Technologies Inc. to focus on advancing glucose-responsive insulins, a future DKA prevention/treatment technology.
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| Company | Key Offerings | Contribution to Diabetic Ketoacidosis (DKA) Treatment Market | Strategic Initiatives | Global Reach |
| Sanofi | Insulins, Glucose monitoring therapies | Expands access to rapid-acting insulins, enhancing emergency DKA management | Focuses on R&D for advanced insulin formulations | Strong presence across North America, Europe, and Asia |
| Biocon Biologics | Biosimilar insulins, affordable biologics | Provides cost-effective insulin biosimilars supporting global DKA care | Partners with Viatris to expand biosimilar insulin reach | Operations in over 100 countries |
| Baxter International Inc. | IV fluids, renal therapies | Supplies life-saving IV solutions for rehydration during DKA | Invests in advanced electrolyte therapy products | Global distribution network across hospitals |
| Fresenius Kabi | Infusion and nutrition products | Enhances DKA stabilization through critical care infusions | Expands production capacity for parenteral nutrition | Active in 100+ healthcare markets |
| B. Braun Melsungen AG | Infusion pumps, insulin delivery systems | Supports precision insulin and fluid therapy in DKA | Innovates digital infusion monitoring systems | Broad European and Asian footprint |
Read further to see how top players are reshaping the Diabetic Ketoacidosis Treatment Market at: https://www.towardshealthcare.com/companies/diabetic-ketoacidosis-treatment-companies
By Treatment Type
By Route of Administration/Product Form
By Care Setting/End User
By Patient Group/Age
By Region
November 2025
November 2025
November 2025
November 2025